{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:29:34Z","timestamp":1793636974868,"version":"4.5.1"},"reference-count":86,"publisher":"Cold Spring Harbor Laboratory","issue":"21-22","funder":[{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012681","name":"CNRS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012681","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Revive","award":["ANR-10-LABX-73"],"award-info":[{"award-number":["ANR-10-LABX-73"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR20CE12002801 CHRODYNE"],"award-info":[{"award-number":["ANR20CE12002801 CHRODYNE"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["LNCC EL2018"],"award-info":[{"award-number":["LNCC EL2018"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["EL2025 NAVARRO"],"award-info":[{"award-number":["EL2025 NAVARRO"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-CoG-2017 BIND"],"award-info":[{"award-number":["ERC-CoG-2017 BIND"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-StG-2019"],"award-info":[{"award-number":["ERC-StG-2019"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laboratoire d'Excellence Who Am I?","award":["11-LABX-0071"],"award-info":[{"award-number":["11-LABX-0071"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"accepted":{"date-parts":[[2026,7,8]]},"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:p>\n                    Faithful genome reactivation after mitosis is essential for cell identity, yet the mechanisms driving global postmitotic transcription remain unclear. Here, we show that the MYC oncogene and its obligate partner MAX drive a postmitotic hypertranscriptional state in mouse embryonic stem cells. Cell cycle\u2013resolved single-cell RNA-seq in inducible\n                    <jats:italic>Max<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    cells reveals that early G1 hypertranscription is strongly impaired without MAX. Mechanistically, MAX remains bound to thousands of promoters during mitosis, while MYC is largely excluded. Using high-temporal-resolution profiling, pharmacological inhibition of MYC\/MAX, and acute MAX degradation at mitotic exit, we demonstrate that MAX mitotic binding triggers rapid MYC recruitment and transcriptional amplification of TBP-bound promoters by enhancing RNA polymerase II occupancy and efficient initiation and elongation. These findings redefine MYC\/MAX as master regulators of gene regulatory inheritance across mitosis.\n                  <\/jats:p>","DOI":"10.1101\/gad.354072.126","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:05:11Z","timestamp":1786043111000},"page":"1871-1884","source":"Crossref","is-referenced-by-count":0,"title":["Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters"],"prefix":"10.1101","volume":"40","author":[{"given":"Inma","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France;"},{"name":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieng","family":"Taing","sequence":"additional","affiliation":[{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France;"},{"name":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almira","family":"Chervova","sequence":"additional","affiliation":[{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France;"},{"name":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Escoll","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 6047, Biologie des Bact\u00e9ries Intracellulaires, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Altamirano-Pacheco","sequence":"additional","affiliation":[{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France;"},{"name":"College Doctoral, Sorbonne Universit\u00e9, Paris 75006, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Sommer","sequence":"additional","affiliation":[{"name":"College Doctoral, Sorbonne Universit\u00e9, Paris 75006, France;"},{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Macrophages and Endothelial Cells Unit, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Urli","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris 75013, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9935-8763","authenticated-orcid":false,"given":"Maxim V.C.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris 75013, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Legros","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris 75013, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Chevreux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, Paris 75013, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Mueller","sequence":"additional","affiliation":[{"name":"Centre de Ressources et Recherches Technologiques (UTechS-PBI, C2RT), Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3691, Photonic Bio-Imaging, Paris 75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France;"},{"name":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2700-6598","authenticated-orcid":false,"given":"Pablo","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Developmental and Stem Cell Biology, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France;"},{"name":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Paris 75015, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"2026110208150811000_40.21-22.1871.1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-6-7"},{"key":"2026110208150811000_40.21-22.1871.2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-1203"},{"key":"2026110208150811000_40.21-22.1871.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0591-3"},{"key":"2026110208150811000_40.21-22.1871.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.2251503"},{"key":"2026110208150811000_40.21-22.1871.5","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.1.71"},{"key":"2026110208150811000_40.21-22.1871.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600279"},{"key":"2026110208150811000_40.21-22.1871.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.013"},{"key":"2026110208150811000_40.21-22.1871.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(97)00207-4"},{"key":"2026110208150811000_40.21-22.1871.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0196-7"},{"key":"2026110208150811000_40.21-22.1871.10","doi-asserted-by":"publisher","DOI":"10.1101\/gad.206458.112"},{"key":"2026110208150811000_40.21-22.1871.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01131-x"},{"key":"2026110208150811000_40.21-22.1871.12","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3891"},{"key":"2026110208150811000_40.21-22.1871.13","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.01-10-0523"},{"key":"2026110208150811000_40.21-22.1871.14","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256075"},{"key":"2026110208150811000_40.21-22.1871.15","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01195-1"},{"key":"2026110208150811000_40.21-22.1871.16","doi-asserted-by":"publisher","DOI":"10.1038\/ncb733"},{"key":"2026110208150811000_40.21-22.1871.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2012.10.004"},{"key":"2026110208150811000_40.21-22.1871.18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"2026110208150811000_40.21-22.1871.19","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201074"},{"key":"2026110208150811000_40.21-22.1871.20","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1906"},{"key":"2026110208150811000_40.21-22.1871.21","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.101"},{"key":"2026110208150811000_40.21-22.1871.22","doi-asserted-by":"publisher","DOI":"10.1038\/363038a0"},{"key":"2026110208150811000_40.21-22.1871.23","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3418"},{"key":"2026110208150811000_40.21-22.1871.24","doi-asserted-by":"publisher","DOI":"10.1101\/gr.243048.118"},{"key":"2026110208150811000_40.21-22.1871.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0343-0"},{"key":"2026110208150811000_40.21-22.1871.26","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay5181"},{"key":"2026110208150811000_40.21-22.1871.27","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a014241"},{"key":"2026110208150811000_40.21-22.1871.28","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.73600.1"},{"key":"2026110208150811000_40.21-22.1871.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.12.009"},{"key":"2026110208150811000_40.21-22.1871.30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009368"},{"key":"2026110208150811000_40.21-22.1871.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01045-1"},{"key":"2026110208150811000_40.21-22.1871.32","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"2026110208150811000_40.21-22.1871.33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09041-z"},{"key":"2026110208150811000_40.21-22.1871.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.04.020"},{"key":"2026110208150811000_40.21-22.1871.35","doi-asserted-by":"publisher","DOI":"10.1101\/gad.280859.116"},{"key":"2026110208150811000_40.21-22.1871.36","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.4.1582-1594.2004"},{"key":"2026110208150811000_40.21-22.1871.37","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.1.44"},{"key":"2026110208150811000_40.21-22.1871.38","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.24.7019"},{"key":"2026110208150811000_40.21-22.1871.39","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-121321-094603"},{"key":"2026110208150811000_40.21-22.1871.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.038"},{"key":"2026110208150811000_40.21-22.1871.41","doi-asserted-by":"publisher","DOI":"10.1101\/gad.335794.119"},{"key":"2026110208150811000_40.21-22.1871.42","unstructured":"Ke G , Meng Q , Finley T , Wang T , Chen W , Ma W , Ye Q , Liu TY . 2017. LightGBM: a highly efficient gradient boosting decision tree. Adv Neural Inf Process Syst 30: 3149\u20133157."},{"key":"2026110208150811000_40.21-22.1871.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.039"},{"key":"2026110208150811000_40.21-22.1871.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.010"},{"key":"2026110208150811000_40.21-22.1871.45","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0619-0"},{"key":"2026110208150811000_40.21-22.1871.46","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3984"},{"key":"2026110208150811000_40.21-22.1871.47","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0414-6"},{"key":"2026110208150811000_40.21-22.1871.48","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"2026110208150811000_40.21-22.1871.49","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-323"},{"key":"2026110208150811000_40.21-22.1871.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.026"},{"key":"2026110208150811000_40.21-22.1871.51","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15161"},{"key":"2026110208150811000_40.21-22.1871.52","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"2026110208150811000_40.21-22.1871.53","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.4.775"},{"key":"2026110208150811000_40.21-22.1871.54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002709"},{"key":"2026110208150811000_40.21-22.1871.55","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01291-6"},{"key":"2026110208150811000_40.21-22.1871.56","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2780"},{"key":"2026110208150811000_40.21-22.1871.57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27345-x"},{"key":"2026110208150811000_40.21-22.1871.58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.033"},{"key":"2026110208150811000_40.21-22.1871.59","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1401"},{"key":"2026110208150811000_40.21-22.1871.60","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2017.82.034280"},{"key":"2026110208150811000_40.21-22.1871.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.02.044"},{"key":"2026110208150811000_40.21-22.1871.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.02.032"},{"key":"2026110208150811000_40.21-22.1871.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.036"},{"key":"2026110208150811000_40.21-22.1871.64","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1011"},{"key":"2026110208150811000_40.21-22.1871.65","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.359"},{"key":"2026110208150811000_40.21-22.1871.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115486"},{"key":"2026110208150811000_40.21-22.1871.67","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad304"},{"key":"2026110208150811000_40.21-22.1871.68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08417-5"},{"key":"2026110208150811000_40.21-22.1871.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.030"},{"key":"2026110208150811000_40.21-22.1871.70","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw257"},{"key":"2026110208150811000_40.21-22.1871.71","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30545-8"},{"key":"2026110208150811000_40.21-22.1871.72","doi-asserted-by":"publisher","DOI":"10.1038\/365359a0"},{"key":"2026110208150811000_40.21-22.1871.73","doi-asserted-by":"publisher","DOI":"10.1038\/nature13537"},{"key":"2026110208150811000_40.21-22.1871.74","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.11.019"},{"key":"2026110208150811000_40.21-22.1871.75","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.22280"},{"key":"2026110208150811000_40.21-22.1871.76","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35621"},{"key":"2026110208150811000_40.21-22.1871.77","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00411-8"},{"key":"2026110208150811000_40.21-22.1871.78","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.8.1493"},{"key":"2026110208150811000_40.21-22.1871.79","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00500-y"},{"key":"2026110208150811000_40.21-22.1871.80","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0321-z"},{"key":"2026110208150811000_40.21-22.1871.81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402770101"},{"key":"2026110208150811000_40.21-22.1871.82","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12609"},{"key":"2026110208150811000_40.21-22.1871.83","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"2026110208150811000_40.21-22.1871.84","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1790"},{"key":"2026110208150811000_40.21-22.1871.85","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2469"},{"key":"2026110208150811000_40.21-22.1871.86","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206641"}],"container-title":["Genes &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gad.354072.126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:15:39Z","timestamp":1793636139000},"score":1,"resource":{"primary":{"URL":"http:\/\/genesdev.cshlp.org\/lookup\/doi\/10.1101\/gad.354072.126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":86,"journal-issue":{"issue":"21-22","published-online":{"date-parts":[[2026,11,2]]},"published-print":{"date-parts":[[2026,11,1]]}},"alternative-id":["10.1101\/gad.354072.126"],"URL":"https:\/\/doi.org\/10.1101\/gad.354072.126","relation":{},"ISSN":["0890-9369","1549-5477"],"issn-type":[{"value":"0890-9369","type":"print"},{"value":"1549-5477","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}