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These B cells have a marked defect in their capacity to secrete immunoglobulin upon mitogenic stimulation in vitro. Thus, Oct-2 is not required for the generation of immunoglobulin-bearing B cells but is crucial for their maturation to immunoglobulin-secreting cells and for another undetermined organismal function.<\/jats:p>","DOI":"10.1101\/gad.7.4.570","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"570-582","source":"Crossref","is-referenced-by-count":213,"title":["Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival."],"prefix":"10.1101","volume":"7","author":[{"given":"L M","family":"Corcoran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Karvelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G J","family":"Nossal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z S","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Jacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Baltimore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"2021111418082797000_7.4.570.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1986.tb01470.x"},{"key":"2021111418082797000_7.4.570.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3317825"},{"key":"2021111418082797000_7.4.570.3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90136-2"},{"key":"2021111418082797000_7.4.570.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.59.070190.004031"},{"key":"2021111418082797000_7.4.570.5","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(89)90197-2"},{"key":"2021111418082797000_7.4.570.6","first-page":"139","article-title":"Signal transduction by B lymphocyte receptors: Structure-function relationships of membrane immunoglobulins and associated molecules.","volume":"2","year":"1990","journal-title":"Semin. 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