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This phenotype is identical to a subset of the effects of embryonic vitamin A deficiency and, therefore, establishes RXR alpha as a genetic component of the vitamin A signaling pathway in cardiac morphogenesis. The cardiac outflow tracts and associated vessels, which are populated by derivatives of the neural crest and which are also sensitive to vitamin A deficiency, are normal in homozygous embryos, indicating the genetic independence of ventricular chamber development. Hepatic differentiation was dramatically but transiently retarded yet is histologically and morphologically normal. These results ascribe an essential function for the RXR alpha gene in embryonic development and provide the first evidence of a requirement for RXR in one of its predicted hormone response pathways.<\/jats:p>","DOI":"10.1101\/gad.8.9.1007","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T17:15:46Z","timestamp":1181063746000},"page":"1007-1018","source":"Crossref","is-referenced-by-count":541,"title":["RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis."],"prefix":"10.1101","volume":"8","author":[{"given":"H M","family":"Sucov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dyson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C L","family":"Gumeringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K R","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1994,5,1]]},"reference":[{"key":"2021111418143996000_8.9.1007.1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90066-4"},{"key":"2021111418143996000_8.9.1007.2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493528"},{"key":"2021111418143996000_8.9.1007.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.55.030193.000453"},{"key":"2021111418143996000_8.9.1007.4","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"2021111418143996000_8.9.1007.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283939"},{"key":"2021111418143996000_8.9.1007.6","unstructured":"Fisher, D. 1986. 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