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However, Atm deficiency failed to rescue deficits in immune differentiation in DNA ligase IV-null mice. These data indicate that ATM responds to endogenous DNA lesions and functions during development to eliminate neural cells that have incurred genomic damage. Therefore, ATM could be important for preventing accumulation of DNA-damaged cells in the nervous system that might eventually lead to the neurodegeneration observed in ataxia telangiectasia.<\/jats:p>","DOI":"10.1101\/gad.837100","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T20:00:34Z","timestamp":1027713634000},"page":"2576-2580","source":"Crossref","is-referenced-by-count":126,"title":["Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm"],"prefix":"10.1101","volume":"14","author":[{"given":"Youngsoo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah E.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2000,10,15]]},"reference":[{"key":"2021111419240227000_14.20.2576.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1674"},{"key":"2021111419240227000_14.20.2576.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)00021-9"},{"key":"2021111419240227000_14.20.2576.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.24.14066"},{"key":"2021111419240227000_14.20.2576.4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202577"},{"key":"2021111419240227000_14.20.2576.5","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1677"},{"key":"2021111419240227000_14.20.2576.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.889"},{"key":"2021111419240227000_14.20.2576.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80156-0"},{"key":"2021111419240227000_14.20.2576.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80264-6"},{"key":"2021111419240227000_14.20.2576.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81714-6"},{"key":"2021111419240227000_14.20.2576.10","doi-asserted-by":"publisher","DOI":"10.1038\/35009138"},{"key":"2021111419240227000_14.20.2576.11","doi-asserted-by":"publisher","DOI":"10.1038\/75508"},{"key":"2021111419240227000_14.20.2576.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01503-9"},{"key":"2021111419240227000_14.20.2576.13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.6.2668"},{"key":"2021111419240227000_14.20.2576.14","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5366.1089"},{"key":"2021111419240227000_14.20.2576.15","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5459.1824"},{"key":"2021111419240227000_14.20.2576.16","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.2307\/3579810","article-title":"Identification of genes involved in repair of DNA double-strand breaks in mammalian cells.","volume":"150","author":"Jeggo","year":"1998","journal-title":"Radiat. 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