{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:31:18Z","timestamp":1770838278781,"version":"3.50.1"},"reference-count":57,"publisher":"Cold Spring Harbor Laboratory","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2001,1,15]]},"abstract":"<jats:p>Mutant <jats:italic>src<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We demonstrate that expression of a truncated Src molecule, Src251, lacking the kinase domain, induces osteopetrosis in wild-type and <jats:italic>src<\/jats:italic><jats:sup>+\/\u2212<\/jats:sup> mice and worsens osteopetrosis in <jats:italic>src<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice by a novel mechanism, increased osteoclast apoptosis. Induction of apoptosis by Src251 requires a functional SH2, but not an SH3, domain and is associated with reduced AKT kinase activity. Expression of Src251 dramatically reduces osteoclast survival in response to RANKL\/TRANCE\/OPGL, providing evidence that Src family kinases are required in vivo for survival signaling pathways downstream from TNF family receptors.<\/jats:p>","DOI":"10.1101\/gad.840301","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T00:00:34Z","timestamp":1027728034000},"page":"241-253","source":"Crossref","is-referenced-by-count":84,"title":["Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival"],"prefix":"10.1101","volume":"15","author":[{"given":"Lianping","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Venegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Garrett-Beal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan F.","family":"Boyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold E.","family":"Varmus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Schwartzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2001,1,15]]},"reference":[{"key":"2021111507321535000_15.2.241.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.8.2251"},{"key":"2021111507321535000_15.2.241.2","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1172\/JCI116032","article-title":"Requirement of pp60c-src expression for osteoclasts to form ruffled borders and to resorb bone in mice.","volume":"90","author":"Boyce","year":"1992","journal-title":"J. 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