{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:01:39Z","timestamp":1792123299410,"version":"4.4.0"},"reference-count":174,"publisher":"Cold Spring Harbor Laboratory","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2001,1,15]]},"DOI":"10.1101\/gad.859401","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T00:00:34Z","timestamp":1027728034000},"page":"111-127","source":"Crossref","is-referenced-by-count":338,"title":["Intercellular signals regulating pancreas development and function"],"prefix":"10.1101","volume":"15","author":[{"given":"Seung K.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hebrok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2001,1,15]]},"reference":[{"key":"2021111507321524000_15.2.111.1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1242\/dev.122.5.1409","article-title":"The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1\/PDX1\u2013deficient mice.","volume":"122","author":"Ahlgren","year":"1996","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.2","doi-asserted-by":"publisher","DOI":"10.1038\/385257a0"},{"key":"2021111507321524000_15.2.111.3","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.12.1763"},{"key":"2021111507321524000_15.2.111.4","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1242\/dev.126.24.5689","article-title":"Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals.","volume":"126","author":"Alexandre","year":"1999","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.5","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1997.062.01.056"},{"key":"2021111507321524000_15.2.111.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00340-X"},{"key":"2021111507321524000_15.2.111.7","doi-asserted-by":"publisher","DOI":"10.1038\/23716"},{"key":"2021111507321524000_15.2.111.8","doi-asserted-by":"publisher","DOI":"10.1038\/372186a0"},{"key":"2021111507321524000_15.2.111.9","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.770"},{"key":"2021111507321524000_15.2.111.10","first-page":"211","article-title":"Hedgehog signaling in animal development and human disease.","volume":"29","author":"Bailey","year":"2000","journal-title":"Ernst Schering Res. Found. Workshop"},{"key":"2021111507321524000_15.2.111.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(200003)22:3<264::AID-BIES8>3.0.CO;2-M"},{"key":"2021111507321524000_15.2.111.12","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090040804"},{"key":"2021111507321524000_15.2.111.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00217-8"},{"key":"2021111507321524000_15.2.111.14","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-353"},{"key":"2021111507321524000_15.2.111.15","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.6.976"},{"key":"2021111507321524000_15.2.111.16","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.0010"},{"key":"2021111507321524000_15.2.111.17","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1242\/dev.124.22.4557","article-title":"The activity of neurogenin1 is controlled by local cues in the zebrafish embryo.","volume":"124","author":"Blader","year":"1997","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80799-0"},{"key":"2021111507321524000_15.2.111.19","first-page":"91","article-title":"Regulation of pancreatic \u03b2-cell mass in vivo.","volume":"49","author":"Bonner-Weir","year":"1994","journal-title":"Recent Prog. Horm. Res."},{"key":"2021111507321524000_15.2.111.20","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-1819-2_39"},{"key":"2021111507321524000_15.2.111.21","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.233"},{"key":"2021111507321524000_15.2.111.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80853-3"},{"key":"2021111507321524000_15.2.111.23","doi-asserted-by":"publisher","DOI":"10.1038\/31933"},{"key":"2021111507321524000_15.2.111.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81893-0"},{"key":"2021111507321524000_15.2.111.25","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1944.02020060002001"},{"key":"2021111507321524000_15.2.111.26","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1242\/dev.109.3.733","article-title":"Lateral inhibition and cell fate during neurogenesis in Drosophila.","volume":"109","author":"Cabrera","year":"1990","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.27","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1642"},{"key":"2021111507321524000_15.2.111.28","doi-asserted-by":"crossref","unstructured":"Cepko C.L. Ryder E.F. Austin C.P. Walsh C. Fekete D.M. (1993) Lineage analysis using retrovirus vectors. in Guide to Techniques in Mouse Development, eds Wassarman P.M. DePamphilis M.L. (Academic Press, Boston), pp 933\u2013961.","DOI":"10.1016\/0076-6879(93)25059-B"},{"key":"2021111507321524000_15.2.111.29","doi-asserted-by":"publisher","DOI":"10.1038\/383407a0"},{"key":"2021111507321524000_15.2.111.30","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.6.1519"},{"key":"2021111507321524000_15.2.111.31","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.6.1445"},{"key":"2021111507321524000_15.2.111.32","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5369.1603"},{"key":"2021111507321524000_15.2.111.33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.2.105"},{"key":"2021111507321524000_15.2.111.34","first-page":"439","article-title":"Ancestrally-duplicated paraHOX gene clusters in humans.","volume":"17","author":"Coulier","year":"2000","journal-title":"Int. J. Oncol."},{"key":"2021111507321524000_15.2.111.35","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2000.6550255.x"},{"key":"2021111507321524000_15.2.111.36","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/dev.122.9.2895","article-title":"Cadherins regulate aggregation of pancreatic \u03b2-cells in vivo.","volume":"122","author":"Dahl","year":"1996","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.37","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1242\/dev.112.4.1115","article-title":"Polyclonal origin of pancreatic islets in aggregation mouse chimaeras.","volume":"112","author":"Deltour","year":"1991","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.38","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90011-4"},{"key":"2021111507321524000_15.2.111.39","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(74)90088-4"},{"key":"2021111507321524000_15.2.111.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00324-X"},{"key":"2021111507321524000_15.2.111.41","doi-asserted-by":"publisher","DOI":"10.2337\/diab.47.2.159"},{"key":"2021111507321524000_15.2.111.42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/33311","article-title":"Regulatory factor linked to late-onset diabetes?","volume":"392","author":"Dutta","year":"1998","journal-title":"Nature"},{"key":"2021111507321524000_15.2.111.43","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90627-3"},{"key":"2021111507321524000_15.2.111.44","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.12.1817"},{"key":"2021111507321524000_15.2.111.45","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.2.325"},{"key":"2021111507321524000_15.2.111.46","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1242\/dev.120.12.3621","article-title":"Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins.","volume":"120","author":"Feijen","year":"1994","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1507\/endocrj.42.63","article-title":"Expression of immunoreactive activin A in fetal rat pancreas.","volume":"42","author":"Furukawa","year":"1995","journal-title":"Endocr. J."},{"key":"2021111507321524000_15.2.111.48","doi-asserted-by":"crossref","unstructured":"Gannon M. Wright C.V.E. (1999) Endodermal patterning and organogenesis. in Cell lineage and fate determination, ed Moody S.A. (Academic Press, San Diego), pp 583\u2013615.","DOI":"10.1016\/B978-012505255-9\/50041-9"},{"key":"2021111507321524000_15.2.111.49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.3.1128"},{"key":"2021111507321524000_15.2.111.50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1242\/dev.122.2.439","article-title":"Lineage-specific morphogenesis in the developing pancreas: Role of mesenchyman factors.","volume":"122","author":"Gittes","year":"1996","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.51","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(62)90042-8"},{"key":"2021111507321524000_15.2.111.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80645-5"},{"key":"2021111507321524000_15.2.111.53","doi-asserted-by":"crossref","unstructured":"Goss R.J. (1978) In. The physiology of growth (Chapters 13,19). (Academic Press, New York).","DOI":"10.1016\/B978-0-12-293055-3.50020-0"},{"key":"2021111507321524000_15.2.111.54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1607"},{"key":"2021111507321524000_15.2.111.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01957-5"},{"key":"2021111507321524000_15.2.111.56","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80024-6"},{"key":"2021111507321524000_15.2.111.57","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7469"},{"key":"2021111507321524000_15.2.111.58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/12674","article-title":"Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.","volume":"23","author":"Harrison","year":"1999","journal-title":"Nat. Genet."},{"key":"2021111507321524000_15.2.111.59","doi-asserted-by":"publisher","DOI":"10.1038\/35048589"},{"key":"2021111507321524000_15.2.111.60","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.12.1458"},{"key":"2021111507321524000_15.2.111.61","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.11.1705"},{"key":"2021111507321524000_15.2.111.62","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1242\/dev.127.22.4905","article-title":"Regulation of pancreas development by Hedgehog signaling.","volume":"127","author":"Hebrok","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.63","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1242\/dev.122.3.1007","article-title":"TGF-\u03b2 signals and a prepattern in Xenopus laevis endodermal development.","volume":"122","author":"Henry","year":"1996","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.64","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1242\/dev.127.11.2317","article-title":"Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages","volume":"127","author":"Herrera","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.65","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1242\/dev.113.4.1257","article-title":"Embryogenesis of the murine endocrine pancreas: Early expression of pancreatic polypeptide gene.","volume":"113","author":"Herrera","year":"1991","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12999"},{"key":"2021111507321524000_15.2.111.67","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80369-8"},{"key":"2021111507321524000_15.2.111.68","unstructured":"Hill D. Lebenthal E. (1993) Congenital abnormalities of the exocrine pancreas. in Pancreas: Biology, pathobiology, and disease, eds Go V.L.W. Dimagno E.P. Gardner J.D. Lebenthal E. Reber H.A. Scheele G.A. (Raven, New York), pp 1029\u20131040."},{"key":"2021111507321524000_15.2.111.69","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2174\/092986730611220401163238","article-title":"Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential.","volume":"6","author":"Holst","year":"1999","journal-title":"Curr. Med. Chem."},{"key":"2021111507321524000_15.2.111.70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000141111","article-title":"An experimental study of regeneration in the islets of Langerhans with reference to the theory of balance.","volume":"27","author":"Hughes","year":"1956","journal-title":"Acta Anat."},{"key":"2021111507321524000_15.2.111.71","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.12.4445-4454.2000"},{"key":"2021111507321524000_15.2.111.72","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.163"},{"key":"2021111507321524000_15.2.111.73","doi-asserted-by":"publisher","DOI":"10.1038\/71657"},{"key":"2021111507321524000_15.2.111.74","doi-asserted-by":"publisher","DOI":"10.1038\/371606a0"},{"key":"2021111507321524000_15.2.111.75","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81125-3"},{"key":"2021111507321524000_15.2.111.76","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.8.1066"},{"key":"2021111507321524000_15.2.111.77","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1016\/S0002-9343(00)00336-3","article-title":"The importance of the \u03b2-cell in the pathogenesis of type 2 diabetes mellitus.","volume":"108","author":"Kahn","year":"2000","journal-title":"Am. J. Med."},{"key":"2021111507321524000_15.2.111.78","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3803"},{"key":"2021111507321524000_15.2.111.79","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1027>3.0.CO;2-8"},{"key":"2021111507321524000_15.2.111.80","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7917"},{"key":"2021111507321524000_15.2.111.81","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.6.876"},{"key":"2021111507321524000_15.2.111.82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13036"},{"key":"2021111507321524000_15.2.111.83","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1242\/dev.124.21.4243","article-title":"Notochord to endoderm signaling is required for pancreas development.","volume":"124","author":"Kim","year":"1997","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.84","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1997.062.01.045"},{"key":"2021111507321524000_15.2.111.85","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1101\/gad.14.15.1866","article-title":"Activin receptor patterning of foregut organogenesis.","volume":"14","author":"Kim","year":"2000","journal-title":"Genes & Dev."},{"key":"2021111507321524000_15.2.111.86","first-page":"110","article-title":"Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.","volume":"4","author":"Kloppel","year":"1985","journal-title":"Surv. Synth. Pathol. Res."},{"key":"2021111507321524000_15.2.111.87","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1620167"},{"key":"2021111507321524000_15.2.111.88","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0002-9440(10)65315-1","article-title":"Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells.","volume":"154","author":"Krakowski","year":"1999","journal-title":"Am. J. Pathol."},{"key":"2021111507321524000_15.2.111.89","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.23.3752"},{"key":"2021111507321524000_15.2.111.90","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90290-9"},{"key":"2021111507321524000_15.2.111.91","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80546-2"},{"key":"2021111507321524000_15.2.111.92","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00317-8"},{"key":"2021111507321524000_15.2.111.93","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.3.442"},{"key":"2021111507321524000_15.2.111.94","doi-asserted-by":"publisher","DOI":"10.2337\/diab.47.8.1236"},{"key":"2021111507321524000_15.2.111.95","first-page":"391","article-title":"Zur Morphologie des Pankreas annulare.","volume":"119","author":"Lecco","year":"1910","journal-title":"Sitzungsber. Oesterr. Akad. Wiss. Math.-Natwiss. CL"},{"key":"2021111507321524000_15.2.111.96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9695"},{"key":"2021111507321524000_15.2.111.97","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/12669","article-title":"Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9.","volume":"23","author":"Li","year":"1999","journal-title":"Nat. Genet."},{"key":"2021111507321524000_15.2.111.98","doi-asserted-by":"publisher","DOI":"10.1038\/1717"},{"key":"2021111507321524000_15.2.111.99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.17.9525"},{"key":"2021111507321524000_15.2.111.100","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7449"},{"key":"2021111507321524000_15.2.111.101","doi-asserted-by":"publisher","DOI":"10.1038\/15500"},{"key":"2021111507321524000_15.2.111.102","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(94)00295-X"},{"key":"2021111507321524000_15.2.111.103","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92814-V"},{"key":"2021111507321524000_15.2.111.104","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.6.627"},{"key":"2021111507321524000_15.2.111.105","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81555-X"},{"key":"2021111507321524000_15.2.111.106","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1242\/dev.127.12.2617","article-title":"Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.","volume":"127","author":"Miettinen","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.107","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1242\/dev.126.20.4431","article-title":"Mouse patched1 controls body size determination and limb patterning.","volume":"126","author":"Milenkovic","year":"1999","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.108","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.143.3.827"},{"key":"2021111507321524000_15.2.111.109","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/dev.125.6.1017","article-title":"Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development.","volume":"125","author":"Miralles","year":"1998","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6267"},{"key":"2021111507321524000_15.2.111.111","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.8.1341"},{"key":"2021111507321524000_15.2.111.112","doi-asserted-by":"crossref","unstructured":"Moskaluk C.A. Kern S.E. (1998) Molecular genetics of pancreatic carcinoma. in Pancreatic cancer pathogenesis, diagnosis, and treatment, ed Reber H.A. (Humana, Totowa, NJ), pp 3\u201320.","DOI":"10.1007\/978-1-4612-1810-4_1"},{"key":"2021111507321524000_15.2.111.113","first-page":"2109","article-title":"Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformations.","volume":"12","author":"Nguyen","year":"1996","journal-title":"Oncogene"},{"key":"2021111507321524000_15.2.111.114","doi-asserted-by":"crossref","unstructured":"Nicholson M.L., Windmill, D.C., Horsburgh, T., and Harris , K.P. Influence of allograft size to recipient body-weight ratio on the long-term outcome of renal transplantation. Br. J. Surg. 87:\u2009314\u2013319..","DOI":"10.1046\/j.1365-2168.2000.01390.x"},{"key":"2021111507321524000_15.2.111.115","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050302"},{"key":"2021111507321524000_15.2.111.116","doi-asserted-by":"publisher","DOI":"10.1038\/31693"},{"key":"2021111507321524000_15.2.111.117","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1242\/dev.122.3.983","article-title":"PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.","volume":"122","author":"Offield","year":"1996","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.118","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80549-A"},{"key":"2021111507321524000_15.2.111.119","doi-asserted-by":"publisher","DOI":"10.1038\/40194"},{"key":"2021111507321524000_15.2.111.120","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.14.1812"},{"key":"2021111507321524000_15.2.111.121","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2337\/diab.31.6.538","article-title":"Macro- and micro-domains in the endocrine pancreas.","volume":"6","author":"Orci","year":"1982","journal-title":"Diabetes"},{"key":"2021111507321524000_15.2.111.122","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0140-6736(75)92078-4","article-title":"Functional subdivision of islets of Langerhans and possible role of D cells.","volume":"2","author":"Orci","year":"1975","journal-title":"Lancet"},{"key":"2021111507321524000_15.2.111.123","unstructured":"Osborne, D., Lee, J.S., Harmon, E.B., Ko, A., Zhang, A.Y., and Kim, S.K. 2000. Smad2 disruption impairs pancreatic \u03b2-cell function and insulin action in mice. Submitted. ."},{"key":"2021111507321524000_15.2.111.124","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1128\/MCB.15.12.7091","article-title":"The Pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: Importance of the FPWMK motif and of the homeodomain.","volume":"15","author":"Peers","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"2021111507321524000_15.2.111.125","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4322"},{"key":"2021111507321524000_15.2.111.126","first-page":"25","article-title":"Development of the embryonic endocrine pancreas.","volume":"1","author":"Pictet","year":"1972","journal-title":"Handbook of physiology"},{"key":"2021111507321524000_15.2.111.127","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.1.305"},{"key":"2021111507321524000_15.2.111.128","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1242\/dev.127.12.2763","article-title":"Hedgehog signals regulate multiple aspects of gastrointestinal development.","volume":"127","author":"Ramalho-Santos","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.129","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9273"},{"key":"2021111507321524000_15.2.111.130","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(94)00342-K"},{"key":"2021111507321524000_15.2.111.131","doi-asserted-by":"publisher","DOI":"10.1038\/368747a0"},{"key":"2021111507321524000_15.2.111.132","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1242\/dev.121.10.3163","article-title":"Sonic hedgehog is an endodermal signal inducing BMP-4 and Hox genes during induction and regionalization of the chick hindgut.","volume":"121","author":"Roberts","year":"1995","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.133","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1242\/dev.125.15.2791","article-title":"Epithelial-mesenchymal signaling during the regionalization of the chick gut.","volume":"125","author":"Roberts","year":"1998","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.134","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90332-W"},{"key":"2021111507321524000_15.2.111.135","first-page":"205","article-title":"An analysis of pancreatic development: Role of mesenchymal factor and other extracellular factors.","volume":"35","author":"Rutter","year":"1978","journal-title":"Symp. Soc. Dev. Biol."},{"key":"2021111507321524000_15.2.111.136","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.6902"},{"key":"2021111507321524000_15.2.111.137","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050118"},{"key":"2021111507321524000_15.2.111.138","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1242\/dev.120.12.3451","article-title":"TBF-\u03b21 influences the relative development of the exocrine and endocrine pancreas in vitro.","volume":"120","author":"Sanvito","year":"1994","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.139","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.21.11307"},{"key":"2021111507321524000_15.2.111.140","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.127.16.3533","article-title":"Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.","volume":"127","author":"Schwitzgebel","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(99)00022-1","article-title":"Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor.","volume":"1450","author":"Shiozaki","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111507321524000_15.2.111.142","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1242\/dev.114.4.939","article-title":"Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo.","volume":"114","author":"Skeath","year":"1992","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.143","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","article-title":"Developmental biology of the pancreas.","volume":"121","author":"Slack","year":"1995","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.144","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.47.1.235"},{"key":"2021111507321524000_15.2.111.145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI113045","article-title":"Stimulation of insulin secretion reveals heterogeneity of pancreatic \u03b2 cells in vivo.","volume":"80","author":"Stefan","year":"1987","journal-title":"J. Clin. Investig."},{"key":"2021111507321524000_15.2.111.146","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.0015"},{"key":"2021111507321524000_15.2.111.147","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/ng1097-138","article-title":"Early-onset type-II diabetes mellitus (MODY-4) linked to IPF1.","volume":"71","author":"Stoffers","year":"1997","journal-title":"Nat. Genet."},{"key":"2021111507321524000_15.2.111.148","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-106"},{"key":"2021111507321524000_15.2.111.149","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00026-5"},{"key":"2021111507321524000_15.2.111.150","first-page":"718","article-title":"Etude immunohistologique de l'expression de glucagon dans l'endoderme pancreatique dorsal chez l'embryon precoce do Poulet.","volume":"181","author":"Sumiya","year":"1987","journal-title":"C.R. Soc. Biol."},{"key":"2021111507321524000_15.2.111.151","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400917"},{"key":"2021111507321524000_15.2.111.152","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1128\/MCB.18.9.5109","article-title":"An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).","volume":"18","author":"Swift","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"2021111507321524000_15.2.111.153","doi-asserted-by":"publisher","DOI":"10.1038\/372182a0"},{"key":"2021111507321524000_15.2.111.154","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.11.1691"},{"key":"2021111507321524000_15.2.111.155","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1242\/dev.127.14.3079","article-title":"Formation of the definitive endoderm in mouse is a Smad2-dependent process.","volume":"127","author":"Tremblay","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.156","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1242\/dev.126.24.5699","article-title":"The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen.","volume":"126","author":"Tribioli","year":"1999","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.157","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1172\/JCI110464","article-title":"Functional differences between rat islets of ventral and dorsal pancreatic origin.","volume":"69","author":"Trimble","year":"1982","journal-title":"J. Clin. Investig."},{"key":"2021111507321524000_15.2.111.158","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0765.1998.tb02293.x","article-title":"EGF and IL-1 \u03b1 modulate the release of collagenase, gelatinase and TIMP-1 as well as the release of calcium by rabbit calvarial bone explants.","volume":"33","author":"van der Zee","year":"1998","journal-title":"J. Periodontal Res."},{"key":"2021111507321524000_15.2.111.159","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.15.8551"},{"key":"2021111507321524000_15.2.111.160","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(95)00395-H"},{"key":"2021111507321524000_15.2.111.161","first-page":"393","article-title":"Diabetes mellitus nach pankreasexstirpation.","volume":"10","author":"von Mering","year":"1889","journal-title":"Zentbl. Klin. Med."},{"key":"2021111507321524000_15.2.111.162","doi-asserted-by":"publisher","DOI":"10.1101\/gad.815400"},{"key":"2021111507321524000_15.2.111.163","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1442"},{"key":"2021111507321524000_15.2.111.164","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1242\/dev.127.8.1563","article-title":"Early mouse endoderm is patterned by soluble factors from adjacent germ layers.","volume":"127","author":"Wells","year":"2000","journal-title":"Development"},{"key":"2021111507321524000_15.2.111.165","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80429-8"},{"key":"2021111507321524000_15.2.111.166","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90042-5"},{"key":"2021111507321524000_15.2.111.167","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200008000-00019"},{"key":"2021111507321524000_15.2.111.168","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.6.1917"},{"key":"2021111507321524000_15.2.111.169","doi-asserted-by":"publisher","DOI":"10.1038\/36116"},{"key":"2021111507321524000_15.2.111.170","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/12631","article-title":"Irs-2 coordinates Igf-1 receptor-mediated \u03b2-cell development and peripheral insulin signalling.","volume":"23","author":"Withers","year":"1999","journal-title":"Nat. Genet."},{"key":"2021111507321524000_15.2.111.171","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81556-1"},{"key":"2021111507321524000_15.2.111.172","first-page":"247","article-title":"Development of pancreatic islets.","volume":"3","author":"Yamaoka","year":"1999","journal-title":"Int. J. Mol. Med."},{"key":"2021111507321524000_15.2.111.173","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2769"},{"key":"2021111507321524000_15.2.111.174","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00326-3"}],"container-title":["Genes &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gad.859401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T04:38:15Z","timestamp":1704429495000},"score":1,"resource":{"primary":{"URL":"http:\/\/genesdev.cshlp.org\/lookup\/doi\/10.1101\/gad.859401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,15]]},"references-count":174,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1,15]]}},"alternative-id":["10.1101\/gad.859401"],"URL":"https:\/\/doi.org\/10.1101\/gad.859401","relation":{},"ISSN":["0890-9369","1549-5477"],"issn-type":[{"value":"0890-9369","type":"print"},{"value":"1549-5477","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,15]]}}}