{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:30:10Z","timestamp":1791117010843,"version":"4.1.0"},"reference-count":32,"publisher":"Cold Spring Harbor Laboratory","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:p>\n                    GATA-family transcription factors are critical to the development of diverse tissues. In particular, GATA-4 has been implicated in formation of the vertebrate heart. As the mouse\n                    <jats:italic>Gata-4<\/jats:italic>\n                    knock-out is early embryonic lethal because of a defect in ventral morphogenesis, the in vivo function of this factor in heart development remains unresolved. To search for a requirement for\n                    <jats:italic>Gata4<\/jats:italic>\n                    in heart development, we created mice harboring a single amino acid replacement in GATA-4 that impairs its physical interaction with its presumptive cardiac cofactor FOG-2.\n                    <jats:italic>Gata4<\/jats:italic>\n                    <jats:sup>ki\/ki<\/jats:sup>\n                    mice die just after embryonic day (E) 12.5 exhibiting features in common with\n                    <jats:italic>Fog2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    embryos as well as additional semilunar cardiac valve defects and a double-outlet right ventricle. These findings establish an intrinsic requirement for GATA-4 in heart development. We also infer that GATA-4 function is dependent on interaction with FOG-2 and, very likely, an additional FOG protein for distinct aspects of heart formation.\n                  <\/jats:p>","DOI":"10.1101\/gad.875201","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T20:00:34Z","timestamp":1027713634000},"page":"839-844","source":"Crossref","is-referenced-by-count":267,"title":["Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors"],"prefix":"10.1101","volume":"15","author":[{"given":"John D.","family":"Crispino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya B.","family":"Lodish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth L.","family":"Thurberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio H.","family":"Litovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tucker","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffery D.","family":"Molkentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart H.","family":"Orkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2001,4,1]]},"reference":[{"key":"2021111507341290000_15.7.839.1","first-page":"2235","article-title":"Mouse GATA-4: A retinoic acid\u2013inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.","volume":"13","author":"Arceci","year":"1993","journal-title":"Mol. 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