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At 8.5 days of gestation, the allantois failed to fuse to the chorion, resulting in abnormal placental development and embryonic death within 1-3 days. In addition, a role for VCAM-1 in early placental formation after chorioallantoic fusion was observed. In a minority of VCAM-1-deficient embryos, the allantois was able to fuse with the chorion, but the allantoic mesoderm was abnormally distributed over the chorionic surface. A small number of VCAM-1-deficient embryos survived, presumably by circumventing the placentation defects. They became viable and fertile adult mice with lack of VCAM-1 expression, normal organs, and an elevated number of circulating blood mononuclear leukocytes.<\/jats:p>","DOI":"10.1101\/gad.9.1.1","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"1-14","source":"Crossref","is-referenced-by-count":326,"title":["Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation."],"prefix":"10.1101","volume":"9","author":[{"given":"G C","family":"Gurtner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"McCoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M I","family":"Cybulsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1995,1,1]]},"reference":[{"issue":"6","key":"2021111418200028000_9.1.1.1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1182\/blood.V57.6.1088.1088","article-title":"Enzyme histochemistry and immunochemistry on biopsy specimens of pathologic human bone marrow.","volume":"57","year":"1981","journal-title":"Blood"},{"key":"2021111418200028000_9.1.1.2","first-page":"488","article-title":"The passive immunity of the young mammal.","volume":"33","year":"1957","journal-title":"Biol. 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