{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:05:32Z","timestamp":1791266732903,"version":"4.1.0"},"reference-count":55,"publisher":"Cold Spring Harbor Laboratory","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1995,5,15]]},"abstract":"<jats:p>YY1 represses transcription when bound upstream of transcriptional initiation sites. This repression can be relieved by adenovirus E1A. Here, we present genetic evidence that the ability of E1A to relieve YY1 repression was impaired by mutations that affect E1A binding to its associated protein p300. This suggests that E1A may modulate the repressor activity of YY1 by binding to p300, which may be physically complexed with YY1. A YY1\/p300 protein complex in vivo was demonstrated by several independent approaches, and the YY1-interacting domain was mapped to the carboxy-terminal region of p300, distinct from the E1A-binding site. Unlike E2F\/RB, the YY1\/p300 complex is not disrupted by E1A. Functional studies using recombinant p300 demonstrated unequivocally that p300 is capable of mediating E1A-induced transcriptional activation through YY1. Taken together, these results reveal, for the first time, a YY1\/p300 complex that is targeted by E1A and demonstrate a function for p300 in mediating interactions between YY1 and E1A. Our data thus identify YY1 as a partner protein for p300 and uncover a molecular mechanism for the relief of YY1-mediated repression by E1A.<\/jats:p>","DOI":"10.1101\/gad.9.10.1188","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"1188-1198","source":"Crossref","is-referenced-by-count":269,"title":["Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300."],"prefix":"10.1101","volume":"9","author":[{"given":"J S","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M","family":"Galvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"See","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Eckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Livingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1995,5,15]]},"reference":[{"key":"2021111418224074000_9.10.1188.1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90127-9"},{"key":"2021111418224074000_9.10.1188.2","doi-asserted-by":"publisher","DOI":"10.1038\/374081a0"},{"key":"2021111418224074000_9.10.1188.3","doi-asserted-by":"publisher","DOI":"10.1038\/370226a0"},{"key":"2021111418224074000_9.10.1188.4","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90112-R"},{"key":"2021111418224074000_9.10.1188.5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90252-0"},{"key":"2021111418224074000_9.10.1188.6","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90333-7"},{"key":"2021111418224074000_9.10.1188.7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90601-A"},{"key":"2021111418224074000_9.10.1188.8","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/jvi.63.8.3479-3488.1989","article-title":"Adeno-associated virus P5 promoter contains an adenovirus E1A-inducible element and a binding site for the Major Late Transcription Factor.","volume":"63","year":"1989","journal-title":"J. Virol."},{"key":"2021111418224074000_9.10.1188.9","first-page":"855","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP.","volume":"265","year":"1993","journal-title":"Nature"},{"key":"2021111418224074000_9.10.1188.10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.5.1475"},{"key":"2021111418224074000_9.10.1188.11","unstructured":"Dyson, N. and E. Harlow. 1992. Adenovirus E1A targets key regulators for cell proliferation. In Cancer surveys (ed. A.J. Levine), pp. 161\u2013195. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York."},{"key":"2021111418224074000_9.10.1188.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.2537532"},{"key":"2021111418224074000_9.10.1188.13","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1128\/jvi.67.12.7641-7647.1993","article-title":"Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.","volume":"67","year":"1993","journal-title":"J. Virol."},{"key":"2021111418224074000_9.10.1188.14","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.8.869"},{"key":"2021111418224074000_9.10.1188.15","doi-asserted-by":"publisher","DOI":"10.1038\/340245a0"},{"key":"2021111418224074000_9.10.1188.16","first-page":"38","article-title":"Cloning of a negative transcription factor that binds to the upstream region of Moloney Murine Leukemia Virus.","volume":"12","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"2021111418224074000_9.10.1188.17","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-36-1-59"},{"key":"2021111418224074000_9.10.1188.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.21.9799"},{"key":"2021111418224074000_9.10.1188.19","first-page":"1579","article-title":"Association of adenovirus early-region 1A proteins with cellular polypeptides.","volume":"6","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"2021111418224074000_9.10.1188.20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5124"},{"key":"2021111418224074000_9.10.1188.21","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90518-7"},{"key":"2021111418224074000_9.10.1188.22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.8.3665"},{"key":"2021111418224074000_9.10.1188.23","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90236-R"},{"key":"2021111418224074000_9.10.1188.24","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90605-3"},{"key":"2021111418224074000_9.10.1188.25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1128\/jvi.53.2.399-409.1985","article-title":"E1a region of human adenovirus and of the highly oncogenic simian adenovirus 7 are closely related.","volume":"53","year":"1985","journal-title":"J. Virol."},{"key":"2021111418224074000_9.10.1188.26","doi-asserted-by":"publisher","DOI":"10.1038\/370223a0"},{"key":"2021111418224074000_9.10.1188.27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.6.925"},{"key":"2021111418224074000_9.10.1188.28","first-page":"1047","article-title":"Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.","volume":"9","year":"1994","journal-title":"Oncogene"},{"key":"2021111418224074000_9.10.1188.29","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90188-5"},{"key":"2021111418224074000_9.10.1188.30","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(80)90138-5"},{"key":"2021111418224074000_9.10.1188.31","doi-asserted-by":"publisher","DOI":"10.1038\/338039a0"},{"key":"2021111418224074000_9.10.1188.32","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90686-9"},{"key":"2021111418224074000_9.10.1188.33","doi-asserted-by":"publisher","DOI":"10.1038\/368520a0"},{"key":"2021111418224074000_9.10.1188.34","doi-asserted-by":"publisher","DOI":"10.1038\/374085a0"},{"key":"2021111418224074000_9.10.1188.35","doi-asserted-by":"publisher","DOI":"10.1126\/science.1654597"},{"key":"2021111418224074000_9.10.1188.36","doi-asserted-by":"publisher","DOI":"10.1038\/295380a0"},{"key":"2021111418224074000_9.10.1188.37","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1128\/jvi.65.12.6397-6406.1991","article-title":"The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site.","volume":"65","year":"1991","journal-title":"J. Virol."},{"key":"2021111418224074000_9.10.1188.38","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.12b.2497"},{"key":"2021111418224074000_9.10.1188.39","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(81)90304-4"},{"key":"2021111418224074000_9.10.1188.40","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(91)90171-Q"},{"key":"2021111418224074000_9.10.1188.41","doi-asserted-by":"publisher","DOI":"10.1126\/science.1411535"},{"key":"2021111418224074000_9.10.1188.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.21.9804"},{"key":"2021111418224074000_9.10.1188.43","first-page":"7487","article-title":"Yin-Yang-1 activates the c-myc promoter.","volume":"13","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"2021111418224074000_9.10.1188.44","unstructured":"Roberson, E.D. 1990. \u201cSequence-directed and protein-induced DNA-bending at a locus involved in the E1A responsiveness of the adeno-associated virus P5 promoter.\u201d Thesis, Princeton University, NJ."},{"key":"2021111418224074000_9.10.1188.45","first-page":"3104","article-title":"The GLI-Kruppel family of human genes.","volume":"8","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"2021111418224074000_9.10.1188.46","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/j.1460-2075.1986.tb04496.x","article-title":"Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes.","volume":"5","year":"1986","journal-title":"EMBO J."},{"key":"2021111418224074000_9.10.1188.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60995-1"},{"key":"2021111418224074000_9.10.1188.48","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1980.044.01.041"},{"key":"2021111418224074000_9.10.1188.49","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90189-6"},{"key":"2021111418224074000_9.10.1188.50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.24.5151"},{"key":"2021111418224074000_9.10.1188.51","first-page":"19","article-title":"Adenovirus 5 El A induced differentiation of P19 embryonal carcinoma cells requires binding to p300.","volume":"10","year":"1995","journal-title":"Oncogene"},{"key":"2021111418224074000_9.10.1188.52","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1128\/jvi.67.1.476-488.1993","article-title":"Identification of specific adenovirus E1A amino-terminal residues critical to the binding of cellular proteins and to the control of cell growth.","volume":"67","year":"1993","journal-title":"J. Virol."},{"key":"2021111418224074000_9.10.1188.53","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90984-7"},{"key":"2021111418224074000_9.10.1188.54","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90299-6"},{"key":"2021111418224074000_9.10.1188.55","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(85)90234-X"}],"container-title":["Genes &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gad.9.10.1188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T02:33:36Z","timestamp":1636943616000},"score":1,"resource":{"primary":{"URL":"http:\/\/genesdev.cshlp.org\/lookup\/doi\/10.1101\/gad.9.10.1188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,15]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,5,15]]}},"alternative-id":["10.1101\/gad.9.10.1188"],"URL":"https:\/\/doi.org\/10.1101\/gad.9.10.1188","relation":{},"ISSN":["0890-9369","1549-5477"],"issn-type":[{"value":"0890-9369","type":"print"},{"value":"1549-5477","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,15]]}}}