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We have cloned the hid gene and find that its expression is sufficient to induce PCD in cell death defective mutants. The hid gene appears to encode a novel 410-amino-acid protein, and its mRNA is expressed in regions of the embryo where cell death occurs. Ectopic expression of hid in the Drosophila retina results in eye ablation. This phenotype can be suppressed completely by expression of the anti-apoptotic p35 protein from baculovirus, indicating that p35 may act genetically downstream from hid.<\/jats:p>","DOI":"10.1101\/gad.9.14.1694","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"1694-1708","source":"Crossref","is-referenced-by-count":642,"title":["The head involution defective gene of Drosophila melanogaster functions in programmed cell death."],"prefix":"10.1101","volume":"9","author":[{"given":"M E","family":"Grether","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Agapite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Steller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1995,7,15]]},"reference":[{"key":"2021111418235851000_9.14.1694.1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/genetics\/129.3.783","article-title":"Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective.","volume":"129","year":"1991","journal-title":"Genetics"},{"key":"2021111418235851000_9.14.1694.2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1242\/dev.117.1.29","article-title":"Programmed cell death during Drosophila embryogenesis.","volume":"117","year":"1993","journal-title":"Development"},{"key":"2021111418235851000_9.14.1694.3","unstructured":"Ashburner, M. 1989. 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