{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:01:56Z","timestamp":1791896516097,"version":"4.3.4"},"reference-count":40,"publisher":"Cold Spring Harbor Laboratory","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1995,10,1]]},"abstract":"<jats:p>Using homologous recombination, mice lacking cyclin D1 were generated by replacing most of the first exon of the Cyl-1 gene with sequences encoding neomycin resistance. Cyl-1(-1-) mice were viable and fertile but consistently smaller than their heterozygous or wild-type littermates. The nullizygous animals also showed two distinctive abnormalities: a severe retinopathy caused by impaired development of all layers of the retina and, in the mammary gland during pregnancy, a marked reduction in acinar development accompanied by a failure to lactate. Approximately 50% of animals also had a malformation of the jaw that manifested itself as a misalignment of the incisor teeth. Mouse embryo fibroblasts isolated from 14 day nullizygous, heterozygous, or wild-type embryos and grown under standard conditions showed similar cell-cycle and growth characteristics. Thus although cyclin D1 kinase activity may facilitate G1 progression, it is not essential for the development of most tissues and organs, and only a few specialized cell lineages are demonstrably sensitive to its absence.<\/jats:p>","DOI":"10.1101\/gad.9.19.2364","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"2364-2372","source":"Crossref","is-referenced-by-count":579,"title":["Mice lacking cyclin D1 are small and show defects in eye and mammary gland development."],"prefix":"10.1101","volume":"9","author":[{"given":"V","family":"Fantl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Stamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Rosewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1995,10,1]]},"reference":[{"key":"2021111418253593000_9.19.2364.1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(87)90214-9"},{"key":"2021111418253593000_9.19.2364.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.20.9571"},{"key":"2021111418253593000_9.19.2364.3","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.5.812"},{"key":"2021111418253593000_9.19.2364.4","first-page":"71","article-title":"CDK5 (PLSTIRE) and CDK4 (PSK-j3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.","volume":"9","year":"1994","journal-title":"Oncogene"},{"key":"2021111418253593000_9.19.2364.5","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.11.1340"},{"key":"2021111418253593000_9.19.2364.6","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/j.1460-2075.1994.tb06488.x","article-title":"Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.","volume":"13","year":"1994","journal-title":"EMBO J."},{"key":"2021111418253593000_9.19.2364.7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90508-4"},{"key":"2021111418253593000_9.19.2364.8","unstructured":"Bradley, A. 1987. Production and analysis of chimeric mice. In Teratocarcinomas and embryonic stem cells: A practical approach (ed. E.J. Robertson), pp. 113\u2013151. IRL Press, Oxford, UK."},{"key":"2021111418253593000_9.19.2364.9","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90507-2"},{"key":"2021111418253593000_9.19.2364.10","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90137-F"},{"key":"2021111418253593000_9.19.2364.11","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90136-E"},{"key":"2021111418253593000_9.19.2364.12","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(90)90009-I"},{"key":"2021111418253593000_9.19.2364.13","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90102-V"},{"key":"2021111418253593000_9.19.2364.14","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90543-6"},{"key":"2021111418253593000_9.19.2364.15","first-page":"3447","article-title":"Overexpression of cyclin d1 in rat fibroblasts causes abnormalities in growth-control, cell-cycle progression and gene-expression.","volume":"8","year":"1993","journal-title":"Oncogene"},{"key":"2021111418253593000_9.19.2364.16","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.3.331"},{"key":"2021111418253593000_9.19.2364.17","first-page":"323","article-title":"Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras-Link between cell-cycle control and malignant transformation.","volume":"9","year":"1994","journal-title":"Oncogene"},{"key":"2021111418253593000_9.19.2364.18","first-page":"707","article-title":"Cyclin D1 protein oscillates and is essential for cell-cycle progression in human tumor-cell lines.","volume":"9","year":"1994","journal-title":"Oncogene"},{"key":"2021111418253593000_9.19.2364.19","first-page":"2125","article-title":"Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types.","volume":"10","year":"1995","journal-title":"Oncogene"},{"key":"2021111418253593000_9.19.2364.20","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90101-4"},{"key":"2021111418253593000_9.19.2364.21","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90360-O"},{"key":"2021111418253593000_9.19.2364.22","first-page":"2066","article-title":"D-type cyclin-dependent kinase-activity in mammalian cells.","volume":"14","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"2021111418253593000_9.19.2364.23","first-page":"2077","article-title":"Identification of G1 kinase-activity for cdk6, a novel cyclin D partner.","volume":"14","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"2021111418253593000_9.19.2364.24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/j.1460-2075.1986.tb04304.x","article-title":"Sequence, topography and protein coding potential of mouse int-2: A putative oncogene activated by mouse mammary tumour virus.","volume":"5","year":"1986","journal-title":"EMBO J."},{"key":"2021111418253593000_9.19.2364.25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.002301"},{"key":"2021111418253593000_9.19.2364.26","doi-asserted-by":"publisher","DOI":"10.1126\/science.2683075"},{"key":"2021111418253593000_9.19.2364.27","first-page":"89","article-title":"The D-type cyclins and their role in tumorigenesis.","volume":"S18","year":"1994","journal-title":"J. Cell. Sci."},{"key":"2021111418253593000_9.19.2364.28","doi-asserted-by":"publisher","DOI":"10.1016\/0960-9822(93)90053-Q"},{"key":"2021111418253593000_9.19.2364.29","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(93)90185-P"},{"key":"2021111418253593000_9.19.2364.30","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.8.1559"},{"key":"2021111418253593000_9.19.2364.31","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(92)90347-A"},{"key":"2021111418253593000_9.19.2364.32","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.08.110192.002525"},{"key":"2021111418253593000_9.19.2364.33","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.3.1669"},{"key":"2021111418253593000_9.19.2364.34","unstructured":"Robertson, E.J. 1987. Embryo-derived stem cell lines. In Teratocarcinomas and embryonic stem cells: A practical approach (ed. E.J. Robertson), pp. 71\u2013112. IRL Press, Oxford, UK."},{"key":"2021111418253593000_9.19.2364.35","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/0092-8674(93)90636-5","article-title":"Mammalian G1-cyclins.","volume":"73","year":"1993","journal-title":"Cell"},{"key":"2021111418253593000_9.19.2364.36","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.10.1149"},{"key":"2021111418253593000_9.19.2364.37","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(95)80112-Y"},{"key":"2021111418253593000_9.19.2364.38","doi-asserted-by":"publisher","DOI":"10.1038\/369669a0"},{"key":"2021111418253593000_9.19.2364.39","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90385-2"},{"key":"2021111418253593000_9.19.2364.40","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90518-H"}],"container-title":["Genes &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gad.9.19.2364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T02:39:59Z","timestamp":1636943999000},"score":1,"resource":{"primary":{"URL":"http:\/\/genesdev.cshlp.org\/lookup\/doi\/10.1101\/gad.9.19.2364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10,1]]},"references-count":40,"journal-issue":{"issue":"19","published-print":{"date-parts":[[1995,10,1]]}},"alternative-id":["10.1101\/gad.9.19.2364"],"URL":"https:\/\/doi.org\/10.1101\/gad.9.19.2364","relation":{},"ISSN":["0890-9369","1549-5477"],"issn-type":[{"value":"0890-9369","type":"print"},{"value":"1549-5477","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10,1]]}}}