{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:48:22Z","timestamp":1791348502339,"version":"4.3.1"},"reference-count":60,"publisher":"Cold Spring Harbor Laboratory","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1995,11,1]]},"abstract":"<jats:p>We have investigated the functional relationships among three loci that are required for multiple alternative cell fate decisions during adult peripheral neurogenesis in Drosophila: Notch (N), which encodes a transmembrane receptor protein, Suppressor of Hairless [Su(H)], which encodes a DNA-binding transcription factor, and the Enhancer of split gene complex [E(spl)-C], which includes seven transcription units that encode basic helix-loop-helix (bHLH) repressor proteins. We describe several lines of evidence establishing that Su(H) directly activates transcription of E(spl)-C genes in response to N receptor activity. Expression of an activated form of the N receptor leads to elevated and ectopic E(spl)-C transcript accumulation and promoter activity in imaginal discs. We show that the proximal upstream regions of three E(spl)-C genes contain multiple specific binding sites for Su(H). The integrity of these sites, as well as Su(H) gene activity, are required not only for normal levels of expression of E(spl)-C genes in imaginal disc proneural clusters, but also for their transcriptional response to hyperactivity of the N receptor. Our results establish Su(H) as a direct regulatory link between N receptor activity and the expression of E(spl)-C genes, extending the known linear structure of the N cell-cell signaling pathway.<\/jats:p>","DOI":"10.1101\/gad.9.21.2609","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"2609-2622","source":"Crossref","is-referenced-by-count":518,"title":["Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity."],"prefix":"10.1101","volume":"9","author":[{"given":"A M","family":"Bailey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Posakony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1995,11,1]]},"reference":[{"key":"2021111418261358000_9.21.2609.1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/genetics\/101.3-4.447","article-title":"The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. 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