{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:59:36Z","timestamp":1791039576959,"version":"4.1.0"},"reference-count":39,"publisher":"Cold Spring Harbor Laboratory","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2002,5,15]]},"abstract":"<jats:p>\n                    During\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    vulval development, activation of receptor tyrosine kinase\/Ras and Notch signaling pathways causes three vulval precursor cells (VPCs) to adopt induced cell fates. A Wnt signaling pathway also acts in cell fate specification by the VPCs, via regulation of the Hox gene\n                    <jats:italic>lin-39<\/jats:italic>\n                    . We show here that either mutation of\n                    <jats:italic>pry-1<\/jats:italic>\n                    or expression of an activated BAR-1 \u03b2-catenin protein causes an Overinduced phenotype, in which greater than three VPCs adopt induced cell fates. This indicates that\n                    <jats:italic>pry-1<\/jats:italic>\n                    , which encodes a\n                    <jats:italic>C. elegans<\/jats:italic>\n                    axin homolog, acts as a negative regulator of Wnt signaling in the VPCs. Loss of activity of the APC homolog\n                    <jats:italic>apr-1<\/jats:italic>\n                    increases the penetrance of this Overinduced phenotype, suggesting that APR-1 may play a negative role in Wnt signaling in this process in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    similar to APC proteins in other systems. The Overinduced phenotype is suppressed by reduction of function of the genes\n                    <jats:italic>pop-1 TCF<\/jats:italic>\n                    and\n                    <jats:italic>lin-39 Hox<\/jats:italic>\n                    . Surprisingly, the Overinduced phenotype caused by hyperactivated Wnt signaling is not dependent on signaling through the Ras pathway. These data suggest that hyperactivation of Wnt signaling is sufficient to cause VPCs to adopt induced fates and that a canonical Wnt pathway may play an important role during\n                    <jats:italic>C. elegans<\/jats:italic>\n                    vulval induction.\n                  <\/jats:p>","DOI":"10.1101\/gad.981602","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T20:00:38Z","timestamp":1027713638000},"page":"1281-1290","source":"Crossref","is-referenced-by-count":97,"title":["Activation of Wnt signaling bypasses the requirement for RTK\/Ras signaling during\n                    <i>C. elegans<\/i>\n                    vulval induction"],"prefix":"10.1101","volume":"16","author":[{"given":"Julie E.","family":"Gleason","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik C.","family":"Korswagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Eisenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2002,5,15]]},"reference":[{"key":"2021111508045396000_16.10.1281.1","unstructured":"Antebi A. Norris C.R. Hedgecock E.M. (1997) Cell and growth cone migrations. in C. elegans II, eds Riddle D.L. Blumenthal T. Meyer B.J. Priess J.R. 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(1997) Development of the Vulva. in C. elegans II, eds Riddle D.L. Blumenthal T. Meyer B.J. Priess J.R. 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