{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:05:26Z","timestamp":1764173126455},"reference-count":46,"publisher":"Cold Spring Harbor Laboratory","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genome Res."],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:p>Prior genetic and physical mapping has shown that the<jats:italic>Naip<\/jats:italic>gene cluster on mouse chromosome 13D1-D3 contains a gene,<jats:italic>Lgn1<\/jats:italic>, that is responsible for determining the permissivity of ex vivo macrophages to<jats:italic>Legionella pneumophila<\/jats:italic>replication. We have identified differences in the structure of the<jats:italic>Naip<\/jats:italic>array among commonly used inbred mouse strains, although these gross structural differences do not correlate with differences in<jats:italic>L. pneumophila<\/jats:italic>permissiveness. A physical map of the region employing clones of the C57BL\/6J haplotype confirms that there are fewer copies of<jats:italic>Naip<\/jats:italic>in this strain than are in the physical map of the 129 haplotype. We have also refined the genetic location of<jats:italic>Lgn1<\/jats:italic>, leaving only<jats:italic>Naip2<\/jats:italic>and<jats:italic>Naip5<\/jats:italic>as candidates for<jats:italic>Lgn1<\/jats:italic>. Our genetic map suggests the presence of two hotspots of recombination within the<jats:italic>Naip<\/jats:italic>array, indicating that the 3\u2032 portion of<jats:italic>Naip<\/jats:italic>may be involved in the genomic instability at this locus.<\/jats:p><jats:p>[The sequence data described in this paper have been submitted to the GenBank data library under accession nos.<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF240489\" ext-link-type=\"gen\" xlink:type=\"simple\">AF240489<\/jats:ext-link>\u2013<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF240530\" ext-link-type=\"gen\" xlink:type=\"simple\">AF240530<\/jats:ext-link>.]<\/jats:p>","DOI":"10.1101\/gr.10.8.1158","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T00:00:34Z","timestamp":1027728034000},"page":"1158-1171","source":"Crossref","is-referenced-by-count":46,"title":["High-resolution Genetic and Physical Map of the<i>Lgn1<\/i>Interval in C57BL\/6J Implicates<i>Naip2<\/i>or<i>Naip5<\/i>in<i>Legionella pneumophila<\/i>Pathogenesis"],"prefix":"10.1101","volume":"10","author":[{"given":"Joseph D.","family":"Growney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2000,8,1]]},"reference":[{"key":"2021111810345313000_10.8.1158.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00356173"},{"key":"2021111810345313000_10.8.1158.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00510-6"},{"key":"2021111810345313000_10.8.1158.3","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1996.0147"},{"key":"2021111810345313000_10.8.1158.4","first-page":"72","article-title":"The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease.","volume":"60","author":"Burglen","year":"1997","journal-title":"Am. 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