{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:57:21Z","timestamp":1791478641410,"version":"4.3.4"},"reference-count":59,"publisher":"Cold Spring Harbor Laboratory","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genome Res."],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>The existence of latent centromeres has been proposed as a possible  explanation for the ectopic emergence of neocentromeres in humans. This  hypothesis predicts an association between the position of neocentromeres and  the position of ancient centromeres inactivated during karyotypic evolution.  Human chromosomal region 15q24-26 is one of several hotspots where multiple  cases of neocentromere emergence have been reported, and it harbors a high  density of chromosome-specific duplicons, rearrangements of which have been  implicated as a susceptibility factor for panic and phobic disorders with  joint laxity. We investigated the evolutionary history of this region in  primates and found that it contains the site of an ancestral centromere which  became inactivated about 25 million years ago, after great apes\/Old World  monkeys diverged. This inactivation has followed a noncentromeric chromosomal  fission of an ancestral chromosome which gave rise to phylogenetic chromosomes  XIV and XV in human and great apes. Detailed mapping of the ancient centromere  and two neocentromeres in 15q24-26 has established that the neocentromere  domains map approximately 8 Mb proximal and 1.5 Mb distal of the ancestral  centromeric region, but that all three map within 500 kb of duplicons, copies  of which flank the centromere in Old World Monkey species. This suggests that  the association between neocentromere and ancestral centromere position on  this chromosome may be due to the persistence of recombinogenic duplications  accrued within the ancient pericentromere, rather than the retention of  \u201ccentromere-competent\u201d sequences per se. The high frequency of  neocentromere emergence in the 15q24-26 region and the high density of  clinically important duplicons are, therefore, understandable in the light of  the evolutionary history of this region.<\/jats:p>","DOI":"10.1101\/gr.1155103","type":"journal-article","created":{"date-parts":[[2003,8,19]],"date-time":"2003-08-19T00:35:34Z","timestamp":1061253334000},"page":"2059-2068","source":"Crossref","is-referenced-by-count":103,"title":["Neocentromeres in 15q24-26 Map to Duplicons Which Flanked an Ancestral Centromere in 15q25"],"prefix":"10.1101","volume":"13","author":[{"given":"Mario","family":"Ventura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Mudge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Burn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pierluigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsetta","family":"Zuffardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Archidiacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Rocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2021111810531477000_13.9.2059.1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1990.9999"},{"key":"2021111810531477000_13.9.2059.2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s00335-001-2100-4","volume":"13","year":"2002","journal-title":"Mamm.  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