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These comparisons have revealed conserved genes, both coding and noncoding, conserved CpG islands and, more surprisingly, conserved pseudogenes. The distribution of repeated elements, especially LINE repeats, in the mouse Xic region when compared to the rest of the genome does not support the hypothesis of a role for these repeat elements in the spreading of X inactivation. Interestingly, an asymmetric distribution of LINE elements on the two DNA strands was observed in the three species, not only within introns but also in intergenic regions. This feature is suggestive of important transcriptional activity within these intergenic regions. In silico prediction followed by experimental analysis has allowed four new genes, <jats:italic>Cnbp2, Ftx, Jpx<\/jats:italic>, and<jats:italic> Ppnx<\/jats:italic>, to be identified and novel, widespread, complex, and apparently noncoding transcriptional activity to be characterized in a region 5\u2032 of <jats:italic>Xist<\/jats:italic> that was recently shown to attract histone modification early after the onset of X inactivation.<\/jats:p><jats:p>[The sequence data described in this paper have been submitted to the EMBL data library under accession nos. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AJ421478\" ext-link-type=\"gen\" xlink:type=\"simple\">AJ421478<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AJ421479\" ext-link-type=\"gen\" xlink:type=\"simple\">AJ421479<\/jats:ext-link>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AJ421480\" ext-link-type=\"gen\" xlink:type=\"simple\">AJ421480<\/jats:ext-link>, and<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AJ421481\" ext-link-type=\"gen\" xlink:type=\"simple\">AJ421481<\/jats:ext-link>. Online supplemental data are available at<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/pbil.univ-lyon1.fr\/datasets\/Xic2002\/data.html\" xlink:type=\"simple\">http:\/\/pbil.univ-lyon1.fr\/datasets\/Xic2002\/data.html<\/jats:ext-link> and<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.genome.org\" xlink:type=\"simple\">www.genome.org<\/jats:ext-link>.]<\/jats:p>","DOI":"10.1101\/gr.152902","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T19:09:30Z","timestamp":1637262570000},"page":"894-908","source":"Crossref","is-referenced-by-count":197,"title":["Comparative Sequence Analysis of the X-Inactivation Center Region in Mouse, Human, and Bovine"],"prefix":"10.1101","volume":"12","author":[{"given":"Corinne","family":"Chureau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Prissette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Bourdet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Barbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Cattolico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Eggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Avner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Duret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2000,11,21]]},"reference":[{"key":"2021111810470138000_12.6.894.1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"2021111810470138000_12.6.894.2","first-page":"29","article-title":"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.","volume":"8","author":"Ansari-Lari","year":"1998","journal-title":"Genome Res."},{"key":"2021111810470138000_12.6.894.3","doi-asserted-by":"publisher","DOI":"10.1038\/35047580"},{"key":"2021111810470138000_12.6.894.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.12.6634"},{"key":"2021111810470138000_12.6.894.5","doi-asserted-by":"publisher","DOI":"10.1101\/gr.10.7.950"},{"key":"2021111810470138000_12.6.894.6","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1128\/MCB.19.2.1479","article-title":"Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.","volume":"19","author":"Bertram","year":"1999","journal-title":"Mol. 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