{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T23:04:26Z","timestamp":1781910266747,"version":"3.54.5"},"reference-count":32,"publisher":"Cold Spring Harbor Laboratory","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genome Res."],"published-print":{"date-parts":[[2001,8,1]]},"abstract":"<jats:p>We have cloned and characterized a novel murine DNA-binding protein Desrt, with a motif characteristic of the ARID (<jats:underline>A<\/jats:underline>-T<jats:underline>r<\/jats:underline>ich<jats:underline>i<\/jats:underline>nteraction<jats:underline>d<\/jats:underline>omain) family of transcription factors. The<jats:italic>Desrt<\/jats:italic>gene encodes an 83-kD protein that is shown to bind DNA and is widely expressed in adult tissues. To examine the in vivo function of<jats:italic>Desrt<\/jats:italic>, we have generated mice with a targeted mutation in the ARID domain of<jats:italic>Desrt<\/jats:italic>. Homozygous mutants have reduced viability, pronounced growth retardation, and a high incidence of abnormalities of the female and male reproductive organs including cryptorchidism. This may thus serve as a model to dissect the mechanisms involved in the development of the reproductive tract including testicular descent. Gene-targeted mice also display a reduction in the thickness of the zona reticularis of the adrenal gland and transient aberrations of the T and B cell compartments of primary lymphoid organs. These data show that this novel DNA-binding protein, Desrt, has a nonredundant function during growth and in the development of the reproductive system.<\/jats:p>","DOI":"10.1101\/gr.168801","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T00:00:34Z","timestamp":1027728034000},"page":"1327-1334","source":"Crossref","is-referenced-by-count":100,"title":["Gene Targeting of Desrt, a Novel ARID Class DNA-Binding Protein, Causes Growth Retardation and Abnormal Development of Reproductive Organs"],"prefix":"10.1101","volume":"11","author":[{"given":"Mireille H.","family":"Lahoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sika","family":"Ristevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deon J.","family":"Venter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars S.","family":"Jermiin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bertoncello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Zavarsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Hasthorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Drago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"de Kretser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Hertzog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Kola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2001,7,12]]},"reference":[{"key":"2021111810455516000_11.8.1327.1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(05)80085-6","article-title":"Role of insulin-like growth factors in embryonic and postnatal growth.","volume":"75","author":"Baker","year":"1993","journal-title":"Cell"},{"key":"2021111810455516000_11.8.1327.2","first-page":"903","article-title":"Effects of an Igf1gene null mutation on mouse reproduction.","volume":"10","author":"Baker","year":"1996","journal-title":"Mol. 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