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Quality-control analyses established the reproducibility of the voxelation procedure. The investigation revealed a common network of coregulated genes shared between the normal and PD brain, and allowed identification of putative control regions responsible for these networks. In addition, genes involved in cell\/cell interactions were found to be prominently regulated in the PD brains. Finally, singular value decomposition (SVD), a mathematical method used to provide parsimonious explanations of complex data sets, identified gene vectors and their corresponding images that distinguished between normal and PD brain structures, most pertinently the striatum.<\/jats:p><jats:p>[All study results and supplementary data are available on the web at<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pharmacology.ucla.edu\/smithlab\/genome_multiplex\" xlink:type=\"simple\">http:\/\/www.pharmacology.ucla.edu\/smithlab\/genome_multiplex<\/jats:ext-link> and at<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.genome.org\" xlink:type=\"simple\">http:\/\/www.genome.org<\/jats:ext-link>. Microarray data are also available at GEO,<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/geo\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/geo<\/jats:ext-link>, under the series accession no. GSE30.]<\/jats:p>","DOI":"10.1101\/gr.229002","type":"journal-article","created":{"date-parts":[[2008,7,19]],"date-time":"2008-07-19T05:41:35Z","timestamp":1216446095000},"page":"868-884","source":"Crossref","is-referenced-by-count":44,"title":["Multiplex Three-Dimensional Brain Gene Expression Mapping in a Mouse Model of Parkinson's Disease"],"prefix":"10.1101","volume":"12","author":[{"given":"Vanessa M.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Ossadtchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshad H.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Yee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Lacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William P.","family":"Melega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon R.","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Leahy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2002,5,16]]},"reference":[{"key":"2021111810470145000_12.6.868.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00439-7"},{"key":"2021111810470145000_12.6.868.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.10101"},{"key":"2021111810470145000_12.6.868.3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130205"},{"key":"2021111810470145000_12.6.868.4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.15"},{"key":"2021111810470145000_12.6.868.5","doi-asserted-by":"publisher","DOI":"10.1038\/4462"},{"key":"2021111810470145000_12.6.868.6","doi-asserted-by":"publisher","DOI":"10.1101\/gr.204102"},{"key":"2021111810470145000_12.6.868.7","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00090.2001"},{"key":"2021111810470145000_12.6.868.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02527709"},{"key":"2021111810470145000_12.6.868.9","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.5804"},{"key":"2021111810470145000_12.6.868.10","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1046\/j.1471-4159.1996.66031222.x","article-title":"Norepinephrine is lateralized within the olfactory bulbs of male mice.","volume":"66","author":"Dluzen","year":"1996","journal-title":"J. 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