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Here, we use prior human cell-based variant-to-gene mapping to nominate six insomnia effector genes and test them in zebrafish, a tractable diurnal vertebrate model well suited for sleep phenotyping. Our CRISPR-based behavioral screening identifies the\n                    <jats:italic>MEIS1<\/jats:italic>\n                    ortholog,\n                    <jats:italic>meis1b<\/jats:italic>\n                    , as a regulator of sleep maintenance, with crispants displaying impaired nighttime-specific sleep maintenance and increased sleep latency. Comparative chromatin analyses reveal conserved regulatory architecture spanning the human insomnia-associated locus and selectively implicate\n                    <jats:italic>meis1b<\/jats:italic>\n                    , whereas the duplicated ohnolog\n                    <jats:italic>meis1a<\/jats:italic>\n                    was dispensable. Developmental profiling further shows that\n                    <jats:italic>meis1b<\/jats:italic>\n                    is expressed in cerebellar granule progenitors, paralleling human\n                    <jats:italic>MEIS1<\/jats:italic>\n                    expression, and that its disruption impairs cerebellar development. Together, these findings establish zebrafish as an efficient vertebrate platform for functional interrogation of GWAS candidates and support an evolutionarily conserved cerebellar role for\n                    <jats:italic>MEIS1<\/jats:italic>\n                    in sleep maintenance.\n                  <\/jats:p>","DOI":"10.1101\/gr.281655.125","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:30:17Z","timestamp":1785443417000},"page":"1785-1799","source":"Crossref","is-referenced-by-count":0,"title":["Cross-species variant-to-function analyses implicate\n                    <i>MEIS1<\/i>\n                    in conferring sleep abnormalities and impaired cerebellar development"],"prefix":"10.1101","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-9059","authenticated-orcid":false,"given":"Amber J.","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Center for Spatial and Functional Genomics, Children's Hospital 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