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This process is applied to defined SNPs in two key enzymes of human red blood cell metabolism: glucose-6-phosphate dehydrogenase and pyruvate kinase. The results demonstrate the utility of in silico models in providing insight into differences between red cell function in patients with chronic and nonchronic anemia. In silico models of complex cellular processes are thus likely to aid in defining and understanding key SNPs in human pathophysiology.<\/jats:p>","DOI":"10.1101\/gr.329302","type":"journal-article","created":{"date-parts":[[2002,11,4]],"date-time":"2002-11-04T23:41:24Z","timestamp":1036453284000},"page":"1687-1692","source":"Crossref","is-referenced-by-count":35,"title":["In Silico Model-Driven Assessment of the Effects of Single Nucleotide Polymorphisms (SNPs) on Human Red Blood Cell Metabolism"],"prefix":"10.1101","volume":"12","author":[{"given":"Neema","family":"Jamshidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon J.","family":"Wiback","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard \u00d8.","family":"Palsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2002,11,1]]},"reference":[{"key":"2021111810473264000_12.11.1687.1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0300-9084(96)89501-0","article-title":"Kinetic and thermodynamic properties of two electrophoretically similar genetic variants of human erythrocyte glucose-6-phosphate dehydrogenase.","volume":"78","author":"Adediran","year":"1996","journal-title":"Biochimie"},{"key":"2021111810473264000_12.11.1687.2","unstructured":"Atkinson D.E. 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