{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:05:29Z","timestamp":1782475529821,"version":"3.54.5"},"reference-count":15,"publisher":"Cold Spring Harbor Laboratory","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genome Res."],"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:p>The <jats:italic>GLC1A<\/jats:italic> gene (which encodes the protein myocilin) has been associated with the development of primary open angle glaucoma. Bacterial artificial chromosomes containing the human <jats:italic>GLC1A<\/jats:italic>gene and its mouse ortholog were subcloned and sequenced to reveal the genomic structure of the genes. Comparison of the coding sequences of the human and mouse <jats:italic>GLC1A<\/jats:italic> genes revealed a high degree of amino acid homology (82%) and the presence of several conserved motifs in the predicted GLC1A proteins. The expression of <jats:italic>GLC1A<\/jats:italic> was examined by Northern blot analysis of RNA from adult human tissues.<jats:italic>GLC1A<\/jats:italic> expression was observed in 17 of 23 tissues tested, suggesting a wider range of expression than was recognized previously. The comparison of the human and mouse <jats:italic>GLC1A<\/jats:italic> genes suggests that the mouse may be a useful model organism in studying the molecular pathophysiology of glaucoma.<\/jats:p><jats:p>[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF049791\" ext-link-type=\"gen\" xlink:type=\"simple\">AF049791<\/jats:ext-link>\u2013<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"AF049796\" ext-link-type=\"gen\" xlink:type=\"simple\">AF049796<\/jats:ext-link>.]<\/jats:p>","DOI":"10.1101\/gr.8.4.377","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:30:58Z","timestamp":1493771458000},"page":"377-384","source":"Crossref","is-referenced-by-count":80,"title":["Characterization and Comparison of the Human and Mouse<i>GLC1A<\/i> Glaucoma\u2009Genes"],"prefix":"10.1101","volume":"8","author":[{"given":"John H.","family":"Fingert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth E.","family":"Swiderski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne M.","family":"Nystuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy C.","family":"Arbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallace L.M.","family":"Alward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val C.","family":"Sheffield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1998,4,1]]},"reference":[{"key":"2021111810274868000_8.4.377.1","doi-asserted-by":"crossref","unstructured":"Alward, W.L.M., J.H. Fingert, M.A. Coote, A.T. Johnson, S.F. Lerner, D. Junqua, F.J. Durcan, P.J. McCartney, D.A. Mackey, V.C. Sheffield, and E.M. Stone. 1998. Clinical features associated with mutations in the chromosome 1 open angle glaucoma gene (GLC1A).New Eng. J. Med. (in press)..","DOI":"10.1056\/NEJM199804093381503"},{"key":"2021111810274868000_8.4.377.2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0003-2697(91)90120-I","article-title":"Fast and sensitive silver staining of DNA in polyacrylamide gels.","volume":"196","author":"Bassam","year":"1991","journal-title":"Ann. Biochem."},{"key":"2021111810274868000_8.4.377.3","doi-asserted-by":"crossref","first-page":"22634","DOI":"10.1016\/S0021-9258(18)54618-4","article-title":"Delayed secondary glucocorticoid response elements.","volume":"266","author":"Chan","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2021111810274868000_8.4.377.4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.11.4535"},{"key":"2021111810274868000_8.4.377.5","doi-asserted-by":"crossref","unstructured":"Kahn H.A. Moorhead H.B. (1973) Statistics on blindness in the model reporting area 1969-70. (U.S. Department of Health, Education, and Welfare Publication), . DHEW Publication no. (NIH) 73\u2013427..","DOI":"10.1097\/00006324-197312000-00022"},{"key":"2021111810274868000_8.4.377.6","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.4682"},{"key":"2021111810274868000_8.4.377.7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/oxfordjournals.aje.a113626","article-title":"The epidemiology of open-angle glaucoma: A review.","volume":"118","author":"Leske","year":"1983","journal-title":"Am. J. Epidemiol."},{"key":"2021111810274868000_8.4.377.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00934-4"},{"key":"2021111810274868000_8.4.377.9","doi-asserted-by":"publisher","DOI":"10.1159\/000310780"},{"key":"2021111810274868000_8.4.377.10","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-47"},{"key":"2021111810274868000_8.4.377.11","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.668"},{"key":"2021111810274868000_8.4.377.12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.9.1.445"},{"key":"2021111810274868000_8.4.377.13","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.9.862"},{"key":"2021111810274868000_8.4.377.14","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070040138048"},{"key":"2021111810274868000_8.4.377.15","unstructured":"Ball S.F. Franklin R.M. , eds(1993) Therapy for glaucoma: Costs and consequences. Transactions of the New Orleans Academy of Ophthalmologists (Kugler, Amsterdam, The Netherlands), pp 61\u201368, ibid."}],"container-title":["Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gr.8.4.377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T18:38:02Z","timestamp":1637260682000},"score":1,"resource":{"primary":{"URL":"http:\/\/genome.cshlp.org\/lookup\/doi\/10.1101\/gr.8.4.377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,1]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4,1]]}},"alternative-id":["10.1101\/gr.8.4.377"],"URL":"https:\/\/doi.org\/10.1101\/gr.8.4.377","relation":{},"ISSN":["1088-9051","1549-5469"],"issn-type":[{"value":"1088-9051","type":"print"},{"value":"1549-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4,1]]}}}