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This has suggested the possibility that narcolepsy may be an autoimmune disorder, a hypothesis that has not been confirmed to date. Genetic factors other than HLA are also likely to be involved. In a canine model of narcolepsy, the disorder is transmitted as a non-MHC single autosomal recessive trait with full penetrance (<jats:italic>canarc-1<\/jats:italic>). A tightly linked marker for<jats:italic>canarc-1<\/jats:italic>has been identified, and positional cloning studies are under way to isolate<jats:italic>canarc-1<\/jats:italic>from a newly developed canine genomic BAC library. The molecular cloning of this gene may lead to a better understanding of sleep mechanisms, as has been the case for circadian rhythms following the cloning of<jats:italic>frq, per,<\/jats:italic>and<jats:italic>Clock.<\/jats:italic><\/jats:p>","DOI":"10.1101\/gr.8.5.427","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:31:11Z","timestamp":1493771471000},"page":"427-434","source":"Crossref","is-referenced-by-count":61,"title":["Genetic Studies in the Sleep Disorder\u2009Narcolepsy"],"prefix":"10.1101","volume":"8","author":[{"given":"Hiroshi","family":"Kadotani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Faraco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mignot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1998,5,1]]},"reference":[{"key":"2021111810275470000_8.5.427.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80495-X"},{"key":"2021111810275470000_8.5.427.2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90121-A"},{"key":"2021111810275470000_8.5.427.3","unstructured":"\u00e2\u0080\u0094\u00e2\u0080\u0094\u00e2\u0080\u0094. 1992. 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