{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:34:58Z","timestamp":1787830498440,"version":"build-2784847793"},"reference-count":23,"publisher":"Cold Spring Harbor Laboratory","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genome Res."],"published-print":{"date-parts":[[1998,8,1]]},"abstract":"\n The change of phenotypic traits in domestic animals and crops as a response to selective breeding mimics the much slower evolutionary change in natural populations. Here, we describe that the dominant white phenotype in domestic pigs is caused by two mutations in the\n KIT<\/jats:italic>\n gene encoding the mast\/stem cell growth factor receptor (MGF), one gene duplication associated with a partially dominant phenotype and a splice mutation in one of the copies leading to the fully dominant allele. The splice mutation is a G to A substitution in the first nucleotide of intron 17 and leads to skipping of exon 17. The duplication is most likely a regulatory mutation affecting KIT expression, whereas the splice mutation is expected to cause a receptor with impaired or absent tyrosine kinase activity. Immunocytochemistry showed that this variant form is expressed in 17- to 19-day-old pig embryos. Hundreds of millions of white pigs around the world are assumed to be heterozygous or homozygous for the two mutations.\n <\/jats:p>\n \n [The EMBL accession numbers for porcine\n KIT1*0101, KIT1*0202, KIT2*0202,<\/jats:italic>\n and\n KIT2*0101<\/jats:italic>\n are\n AJ223228<\/jats:ext-link>\n \u2013\n AJ223231<\/jats:ext-link>\n , respectively.]\n <\/jats:p>","DOI":"10.1101\/gr.8.8.826","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T20:32:46Z","timestamp":1493757166000},"page":"826-833","source":"Crossref","is-referenced-by-count":146,"title":["Molecular Basis for the Dominant White Phenotype in the Domestic Pig"],"prefix":"10.1101","volume":"8","author":[{"given":"Stefan","family":"Marklund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kijas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heriberto","family":"Rodriguez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"R\u00f6nnstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Funa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Edfors-Lilja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"2021111810281241000_8.8.826.1","unstructured":"Anonymous (1990) SAS v. 6.10. 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Hered."},{"key":"2021111810281241000_8.8.826.18","first-page":"2545","article-title":"High-frequency germ line gene conversion in transgenic mice.","volume":"12","author":"Murti","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"2021111810281241000_8.8.826.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4320(96)01610-7"},{"key":"2021111810281241000_8.8.826.20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.1.153"},{"key":"2021111810281241000_8.8.826.21","first-page":"71","article-title":"Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease.","volume":"142","author":"Waltenberger","year":"1993","journal-title":"Am. J. Pathol."},{"key":"2021111810281241000_8.8.826.22","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950190411"},{"key":"2021111810281241000_8.8.826.23","unstructured":"Wiseman J. (1986) A history of the British pig. (Ebenezer Baylis & Son Ltd. Worcester, UK)."}],"container-title":["Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/gr.8.8.826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:22:54Z","timestamp":1692775374000},"score":1,"resource":{"primary":{"URL":"http:\/\/genome.cshlp.org\/lookup\/doi\/10.1101\/gr.8.8.826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8,1]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1998,8,1]]}},"alternative-id":["10.1101\/gr.8.8.826"],"URL":"https:\/\/doi.org\/10.1101\/gr.8.8.826","relation":{},"ISSN":["1088-9051","1549-5469"],"issn-type":[{"value":"1088-9051","type":"print"},{"value":"1549-5469","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8,1]]}}}