{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:05:51Z","timestamp":1783069551806,"version":"3.54.6"},"reference-count":67,"publisher":"Cold Spring Harbor Laboratory","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Learn. Mem."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Latent inhibition (LI) is a decrement in learning performance that results from the nonreinforced pre-exposure of the to-be-conditioned stimulus, in both vertebrates and invertebrates. In vertebrates, LI development involves dopamine and serotonin; in invertebrates there is yet no information. We studied differential olfactory conditioning of the proboscis extension response in the honeybee <jats:italic>Apis mellifera<\/jats:italic>, and we compared LI in individuals treated with antagonists of biogenic amines (dopamine, octopamine, and serotonin). An antagonist of octopamine receptors and two antagonists of serotonin receptors showed LI disruption. We thus provide evidence that serotonin would participate in the regulation of LI in honeybees.<\/jats:p>","DOI":"10.1101\/lm.028167.112","type":"journal-article","created":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T06:32:49Z","timestamp":1353133969000},"page":"593-597","source":"Crossref","is-referenced-by-count":19,"title":["Latent inhibition in an insect: The role of aminergic signaling"],"prefix":"10.1101","volume":"19","author":[{"given":"Vanesa M.","family":"Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Giurfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Devaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter M.","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"2021111206200887000_19.12.593.1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03200054"},{"key":"2021111206200887000_19.12.593.2","doi-asserted-by":"publisher","DOI":"10.1037\/h0028159"},{"key":"2021111206200887000_19.12.593.3","doi-asserted-by":"publisher","DOI":"10.1038\/337033a0"},{"key":"2021111206200887000_19.12.593.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.06.011"},{"key":"2021111206200887000_19.12.593.5","first-page":"107","article-title":"Classical conditioning of proboscis extension in honeybees","volume":"97","year":"1983","journal-title":"J Comp Physiol A"},{"key":"2021111206200887000_19.12.593.6","doi-asserted-by":"publisher","DOI":"10.1002\/arch.1055"},{"key":"2021111206200887000_19.12.593.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2005.11.015"},{"key":"2021111206200887000_19.12.593.8","first-page":"169","article-title":"Caracter\u00edsticas experimentales y neurobiolog\u00eda de la inhibici\u00f3n latente en el paradigma de aprendizaje aversivo gustativo","volume":"27","year":"2006","journal-title":"Psicol\u00f3gica"},{"key":"2021111206200887000_19.12.593.9","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7036.114.1.86"},{"key":"2021111206200887000_19.12.593.10","first-page":"805","article-title":"Latent inhibition in the honey bee, Apis mellifera: Is it a unitary phenomenon?","volume":"10","year":"2010","journal-title":"Anim Cogn"},{"key":"2021111206200887000_19.12.593.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.12.5441"},{"key":"2021111206200887000_19.12.593.12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703338"},{"key":"2021111206200887000_19.12.593.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05904.x"},{"key":"2021111206200887000_19.12.593.14","doi-asserted-by":"publisher","DOI":"10.1080\/00221300309601169"},{"key":"2021111206200887000_19.12.593.15","doi-asserted-by":"publisher","DOI":"10.1007\/BF01929916"},{"key":"2021111206200887000_19.12.593.16","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.1523\/JNEUROSCI.23-12-05370.2003","article-title":"Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2021111206200887000_19.12.593.17","doi-asserted-by":"publisher","DOI":"10.1006\/anbe.2000.1635"},{"key":"2021111206200887000_19.12.593.18","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-009-0453-4"},{"key":"2021111206200887000_19.12.593.19","doi-asserted-by":"publisher","DOI":"10.1007\/s10071-010-0363-4"},{"key":"2021111206200887000_19.12.593.20","doi-asserted-by":"crossref","unstructured":"Gaddes WH , Edgell D . 1994. Learning disabilities and brain function: A neuropsychological approach. Springer-Verlag, New York.","DOI":"10.1007\/978-1-4757-2255-0"},{"key":"2021111206200887000_19.12.593.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.09.021"},{"key":"2021111206200887000_19.12.593.22","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-007-0235-9"},{"key":"2021111206200887000_19.12.593.23","doi-asserted-by":"publisher","DOI":"10.1101\/lm.024711.111"},{"key":"2021111206200887000_19.12.593.24","doi-asserted-by":"publisher","DOI":"10.1038\/366059a0"},{"key":"2021111206200887000_19.12.593.25","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1523\/JNEUROSCI.15-03-01617.1995","article-title":"Learning and memory in the honeybee","volume":"15","year":"1995","journal-title":"J Neurosci"},{"key":"2021111206200887000_19.12.593.26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1101\/lm.5.1.146","article-title":"Multiple sites of associative odor learning as revealed by local brain microinjections of octopamine in honeybees","volume":"5","year":"1998","journal-title":"Learn Mem"},{"key":"2021111206200887000_19.12.593.27","first-page":"266","article-title":"Mushroom body memoir: From maps to models","volume":"4","year":"2003","journal-title":"Nature"},{"key":"2021111206200887000_19.12.593.28","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.048256"},{"key":"2021111206200887000_19.12.593.29","doi-asserted-by":"crossref","unstructured":"James W . 1890. Principles of psychology. Henry Holt, New York.","DOI":"10.1037\/10538-000"},{"key":"2021111206200887000_19.12.593.30","doi-asserted-by":"publisher","DOI":"10.1126\/science.2902685"},{"key":"2021111206200887000_19.12.593.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2003.10.003"},{"key":"2021111206200887000_19.12.593.32","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903480408"},{"key":"2021111206200887000_19.12.593.33","doi-asserted-by":"publisher","DOI":"10.3758\/BF03192885"},{"key":"2021111206200887000_19.12.593.34","doi-asserted-by":"publisher","DOI":"10.1037\/h0034425"},{"key":"2021111206200887000_19.12.593.35","doi-asserted-by":"publisher","DOI":"10.1037\/h0046700"},{"key":"2021111206200887000_19.12.593.36","doi-asserted-by":"crossref","unstructured":"Lubow R , Weiner I . 2010. Latent inhibition: cognition, neuroscience and application to schizophrenia. Cambridge University Press, Cambridge, UK.","DOI":"10.1017\/CBO9780511730184"},{"key":"2021111206200887000_19.12.593.37","first-page":"1","article-title":"Conditioned attention theory","volume-title":"The psychology of learning and motivation","volume":"Vol. 15","year":"1981"},{"key":"2021111206200887000_19.12.593.38","doi-asserted-by":"publisher","DOI":"10.1037\/h0076778"},{"key":"2021111206200887000_19.12.593.39","doi-asserted-by":"publisher","DOI":"10.1007\/s003590050392"},{"key":"2021111206200887000_19.12.593.40","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1178-80"},{"key":"2021111206200887000_19.12.593.41","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.113.4.744"},{"key":"2021111206200887000_19.12.593.42","doi-asserted-by":"publisher","DOI":"10.1007\/BF00619340"},{"key":"2021111206200887000_19.12.593.43","first-page":"1","article-title":"Roles of aminergic neurons in formation and recall of associative memory in crickets","volume":"4","year":"2010","journal-title":"Front Behav Neurosci"},{"key":"2021111206200887000_19.12.593.44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3758\/BF03332852","article-title":"Formation of attentional-associative networks in real time: Role of the hippocampus and implications for conditioning","volume":"8","year":"1980","journal-title":"Physiol Psychol"},{"key":"2021111206200887000_19.12.593.45","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-003-0442-y"},{"key":"2021111206200887000_19.12.593.46","unstructured":"Pavlov IP . 1927. Lectures on conditioned reflexes. International Publishers, New York."},{"key":"2021111206200887000_19.12.593.47","doi-asserted-by":"publisher","DOI":"10.1016\/0023-9690(72)90020-3"},{"key":"2021111206200887000_19.12.593.48","doi-asserted-by":"publisher","DOI":"10.1037\/h0027760"},{"key":"2021111206200887000_19.12.593.49","doi-asserted-by":"publisher","DOI":"10.1037\/h0030694"},{"key":"2021111206200887000_19.12.593.50","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00016-7"},{"key":"2021111206200887000_19.12.593.51","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.50.071803.130404"},{"key":"2021111206200887000_19.12.593.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00192-7"},{"key":"2021111206200887000_19.12.593.53","doi-asserted-by":"publisher","DOI":"10.1006\/anbe.2000.1395"},{"key":"2021111206200887000_19.12.593.54","doi-asserted-by":"publisher","DOI":"10.2174\/157015906778520791"},{"key":"2021111206200887000_19.12.593.55","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0166-4328(89)80083-X","article-title":"Effects of hippocampal manipulations on the classically conditioned nictitating membrane response: Simulations by an attentional-associative model","volume":"32","year":"1989","journal-title":"Behav Brain Res"},{"key":"2021111206200887000_19.12.593.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2006.07.023"},{"key":"2021111206200887000_19.12.593.57","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-006-0197-1"},{"key":"2021111206200887000_19.12.593.58","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902250407"},{"key":"2021111206200887000_19.12.593.59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014536"},{"key":"2021111206200887000_19.12.593.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00142-5"},{"key":"2021111206200887000_19.12.593.61","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1325-6"},{"key":"2021111206200887000_19.12.593.62","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(61)90060-9"},{"key":"2021111206200887000_19.12.593.63","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00320-2"},{"key":"2021111206200887000_19.12.593.64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000288"},{"key":"2021111206200887000_19.12.593.65","unstructured":"Wagner AR , Rescorla RA . 1972. Inhibition in pavlovian conditioning: application of a theory. In Inhibition and learning (ed. Boakes, RA Halliday MS ), pp. 301\u2013336. Academic Press, New York."},{"key":"2021111206200887000_19.12.593.66","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1313-x"},{"key":"2021111206200887000_19.12.593.67","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/25.4.473"}],"container-title":["Learning &amp; Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/lm.028167.112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T14:20:50Z","timestamp":1636726850000},"score":1,"resource":{"primary":{"URL":"http:\/\/learnmem.cshlp.org\/lookup\/doi\/10.1101\/lm.028167.112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,16]]},"references-count":67,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2012,11,16]]},"published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1101\/lm.028167.112"],"URL":"https:\/\/doi.org\/10.1101\/lm.028167.112","relation":{},"ISSN":["1549-5485"],"issn-type":[{"value":"1549-5485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,16]]}}}