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Using the contextual fear conditioning paradigm in rats, we found that the endogenous content of an aversive memory can be updated during its reconsolidation incorporating consequences of natural events such as water deprivation, transforming a previously stored memory into a state-dependent one. This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation. Systemic morphine injection was also able to turn a previously acquired experience into a state-dependent memory, reproducing the very same effects obtained by water deprivation or local angiotensin II infusion, and suggesting that other state-dependent-inducing protocols would also be able to contribute to memory updating. These findings trigger new insights about the influence of ordinary daily life events upon memory in its continuing reconstruction, adding the realm of reconsolidation to the classical view of endogenous modulation of consolidation.<\/jats:p>","DOI":"10.1101\/lm.030023.112","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T03:36:42Z","timestamp":1371699402000},"page":"379-387","source":"Crossref","is-referenced-by-count":37,"title":["Reconsolidation may incorporate state-dependency into previously consolidated memories"],"prefix":"10.1101","volume":"20","author":[{"given":"Rodrigo O.","family":"Sierra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey 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