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It has been proposed that memory destabilization could be critical in this sense. Using contextual fear conditioning in rats and midazolam as an amnesic agent, we first determined what reactivation conditions are necessary to destabilize the mnemonic trace. After establishing the conditions for memory destabilization, a series of experiments was conducted to determine if destabilization is critical for the success of the reactivation\u2013extinction procedure. Data confirmed the importance of memory destabilization prior to extinction inside the reconsolidation window to attenuate spontaneous recovery and retard reacquisition of conditioned fear. The present report offers a candidate explanation of the discrepancy in results obtained with the reactivation\u2013extinction procedure by different laboratories.<\/jats:p>","DOI":"10.1101\/lm.032714.113","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T07:00:28Z","timestamp":1387436428000},"page":"46-54","source":"Crossref","is-referenced-by-count":48,"title":["Memory destabilization is critical for the success of the reactivation\u2013extinction procedure"],"prefix":"10.1101","volume":"21","author":[{"given":"Marcelo E.","family":"Pi\u00f1eyro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roque I.","family":"Ferrer Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn M.","family":"Alfei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n M.","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo P.","family":"Urcelay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"2021111207235735000_21.1.46.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223006"},{"key":"2021111207235735000_21.1.46.2","first-page":"1","article-title":"Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes","volume":"2","year":"2012","journal-title":"Transl Psychiatry"},{"key":"2021111207235735000_21.1.46.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3004-1"},{"key":"2021111207235735000_21.1.46.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.07.002"},{"key":"2021111207235735000_21.1.46.5","doi-asserted-by":"publisher","DOI":"10.1037\/h0027676"},{"key":"2021111207235735000_21.1.46.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01546-9"},{"key":"2021111207235735000_21.1.46.7","doi-asserted-by":"publisher","DOI":"10.1101\/lm.78804"},{"key":"2021111207235735000_21.1.46.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.12.064"},{"key":"2021111207235735000_21.1.46.9","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.75"},{"key":"2021111207235735000_21.1.46.10","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.215"},{"key":"2021111207235735000_21.1.46.11","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1912510"},{"key":"2021111207235735000_21.1.46.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2006.10.002"},{"key":"2021111207235735000_21.1.46.13","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195298"},{"key":"2021111207235735000_21.1.46.14","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2175811"},{"key":"2021111207235735000_21.1.46.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.01.053"},{"key":"2021111207235735000_21.1.46.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.03.010"},{"key":"2021111207235735000_21.1.46.17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086881"},{"key":"2021111207235735000_21.1.46.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.03.008"},{"key":"2021111207235735000_21.1.46.19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1496"},{"key":"2021111207235735000_21.1.46.20","doi-asserted-by":"publisher","DOI":"10.1101\/lm.026054.112"},{"key":"2021111207235735000_21.1.46.21","first-page":"1","article-title":"Are memories erasable? 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