{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:21:36Z","timestamp":1791213696757,"version":"4.1.0"},"reference-count":195,"publisher":"Cold Spring Harbor Laboratory","issue":"10","funder":[{"name":"Queen Elisabeth Foundation","award":["VIB"],"award-info":[{"award-number":["VIB"]}]},{"name":"Queen Elisabeth Foundation","award":["SAO"],"award-info":[{"award-number":["SAO"]}]},{"name":"Queen Elisabeth Foundation","award":["FWO-G.0705.11"],"award-info":[{"award-number":["FWO-G.0705.11"]}]},{"name":"Queen Elisabeth Foundation","award":["FWO-G.0667.09"],"award-info":[{"award-number":["FWO-G.0667.09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Learn. Mem."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet expansion that inhibits the expression of the<jats:italic>FMR1<\/jats:italic>gene. The gene product, the Fragile X Mental Retardation Protein (FMRP), regulates mRNA metabolism in brain and nonneuronal cells. During brain development, FMRP controls the expression of key molecules involved in receptor signaling, cytoskeleton remodeling, protein synthesis and, ultimately, spine morphology. Symptoms associated with FXS include neurodevelopmental delay, cognitive impairment, anxiety, hyperactivity, and autistic-like behavior. Twenty years ago the first<jats:italic>Fmr1<\/jats:italic>KO mouse to study FXS was generated, and several years later other key models including the mutant<jats:italic>Drosophila melanogaster<\/jats:italic>,<jats:italic>dFmr1<\/jats:italic>, have further helped the understanding of the cellular and molecular causes behind this complex syndrome. Here, we review to which extent these biological models are affected by the absence of FMRP, pointing out the similarities with the observed human dysfunction. Additionally, we discuss several potential treatments under study in animal models that are able to partially revert some of the FXS abnormalities.<\/jats:p>","DOI":"10.1101\/lm.035956.114","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T04:02:19Z","timestamp":1410926539000},"page":"543-555","source":"Crossref","is-referenced-by-count":84,"title":["Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us"],"prefix":"10.1101","volume":"21","author":[{"given":"Ana Rita","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros K.","family":"Kanellopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"2021111207265772000_21.10.543.1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.661908"},{"key":"2021111207265772000_21.10.543.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1667"},{"key":"2021111207265772000_21.10.543.3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63141"},{"key":"2021111207265772000_21.10.543.4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1601-183X.2010.00585.x","article-title":"Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments","volume":"9","year":"2010","journal-title":"Genes Brain Behav"},{"key":"2021111207265772000_21.10.543.5","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.068908"},{"key":"2021111207265772000_21.10.543.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.04.009"},{"key":"2021111207265772000_21.10.543.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80736-9"},{"key":"2021111207265772000_21.10.543.8","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162201002833"},{"key":"2021111207265772000_21.10.543.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.12.001"},{"key":"2021111207265772000_21.10.543.10","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.063701"},{"key":"2021111207265772000_21.10.543.11","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004214"},{"key":"2021111207265772000_21.10.543.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.022"},{"key":"2021111207265772000_21.10.543.13","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2008.061796"},{"key":"2021111207265772000_21.10.543.14","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2175"},{"key":"2021111207265772000_21.10.543.15","doi-asserted-by":"publisher","DOI":"10.4161\/fly.4.3.12280"},{"key":"2021111207265772000_21.10.543.16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1978.tb01390.x"},{"key":"2021111207265772000_21.10.543.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.02.006"},{"key":"2021111207265772000_21.10.543.18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4830-08.2009"},{"key":"2021111207265772000_21.10.543.19","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3127"},{"key":"2021111207265772000_21.10.543.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.05.004"},{"key":"2021111207265772000_21.10.543.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2005.12.008"},{"key":"2021111207265772000_21.10.543.22","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.78"},{"key":"2021111207265772000_21.10.543.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00036-7"},{"key":"2021111207265772000_21.10.543.24","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-009-9259-6"},{"key":"2021111207265772000_21.10.543.25","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.004598"},{"key":"2021111207265772000_21.10.543.26","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr527"},{"key":"2021111207265772000_21.10.543.27","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-010-9067-y"},{"key":"2021111207265772000_21.10.543.28","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)90237-2"},{"key":"2021111207265772000_21.10.543.29","doi-asserted-by":"crossref","unstructured":"Curzon P , Rustay NR , Browman KE . 2009. Cued and contextual fear conditioning for rodents. In Methods of behavior analysis in neuroscience (ed. Buccafusco JJ ), pp. 19\u201337, chapter 2. CRC Press, Boca Raton, FL.","DOI":"10.1201\/NOE1420052343.ch2"},{"key":"2021111207265772000_21.10.543.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.09.006"},{"key":"2021111207265772000_21.10.543.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.04.058"},{"key":"2021111207265772000_21.10.543.32","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3379"},{"key":"2021111207265772000_21.10.543.33","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90266-T"},{"key":"2021111207265772000_21.10.543.34","doi-asserted-by":"publisher","DOI":"10.1038\/ng0193-31"},{"key":"2021111207265772000_21.10.543.35","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0932-8_23"},{"key":"2021111207265772000_21.10.543.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.039"},{"key":"2021111207265772000_21.10.543.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.04.002"},{"key":"2021111207265772000_21.10.543.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00224-2"},{"key":"2021111207265772000_21.10.543.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.06.003"},{"key":"2021111207265772000_21.10.543.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00724-9"},{"key":"2021111207265772000_21.10.543.41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219383110"},{"key":"2021111207265772000_21.10.543.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.001"},{"key":"2021111207265772000_21.10.543.43","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00030"},{"key":"2021111207265772000_21.10.543.44","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2475"},{"key":"2021111207265772000_21.10.543.45","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90569-X"},{"key":"2021111207265772000_21.10.543.46","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-75681-3_19"},{"key":"2021111207265772000_21.10.543.47","first-page":"191","article-title":"The FMRP regulon: from targets to disease convergence","volume":"7","year":"2013","journal-title":"Front Neurosci"},{"key":"2021111207265772000_21.10.543.48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.11.015"},{"key":"2021111207265772000_21.10.543.49","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(02)00158-3"},{"key":"2021111207265772000_21.10.543.50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001432"},{"key":"2021111207265772000_21.10.543.51","doi-asserted-by":"publisher","DOI":"10.1038\/nature12929"},{"key":"2021111207265772000_21.10.543.52","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90283-5"},{"key":"2021111207265772000_21.10.543.53","first-page":"155","article-title":"Sequence of abnormal dendritic spine development in primary somatosensory cortex of a mouse model of the fragile X mental retardation syndrome","volume":"135","year":"2005","journal-title":"Am J Med Genet A"},{"key":"2021111207265772000_21.10.543.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.08.009"},{"key":"2021111207265772000_21.10.543.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00740-7"},{"key":"2021111207265772000_21.10.543.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.10.006"},{"key":"2021111207265772000_21.10.543.57","doi-asserted-by":"publisher","DOI":"10.1242\/dev.022244"},{"key":"2021111207265772000_21.10.543.58","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.04.008.2009"},{"key":"2021111207265772000_21.10.543.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.01.008"},{"key":"2021111207265772000_21.10.543.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.11.006"},{"key":"2021111207265772000_21.10.543.61","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960809)64:2<246::AID-AJMG2>3.0.CO;2-S"},{"key":"2021111207265772000_21.10.543.62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2012.00781.x"},{"key":"2021111207265772000_21.10.543.63","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.857400"},{"key":"2021111207265772000_21.10.543.64","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001211)95:4<307::AID-AJMG3>3.0.CO;2-3"},{"key":"2021111207265772000_21.10.543.65","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.34.1.205"},{"key":"2021111207265772000_21.10.543.66","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.137"},{"key":"2021111207265772000_21.10.543.67","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2336"},{"key":"2021111207265772000_21.10.543.68","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr501"},{"key":"2021111207265772000_21.10.543.69","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.5.753"},{"key":"2021111207265772000_21.10.543.70","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1542\/peds.97.1.122","article-title":"Learning-disabled males with a fragile X CGG expansion in the upper premutation size range","volume":"97","year":"1996","journal-title":"Pediatrics"},{"key":"2021111207265772000_21.10.543.71","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-21649-7_17"},{"key":"2021111207265772000_21.10.543.72","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13r08714"},{"key":"2021111207265772000_21.10.543.73","doi-asserted-by":"publisher","DOI":"10.1126\/science.8209251"},{"key":"2021111207265772000_21.10.543.74","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.110129"},{"key":"2021111207265772000_21.10.543.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.05.003"},{"key":"2021111207265772000_21.10.543.76","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705003104"},{"key":"2021111207265772000_21.10.543.77","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1399-0004.1985.tb01227.x","article-title":"Detection of fragile sites on human chromosomes","volume":"28","year":"1985","journal-title":"Clin Genet"},{"key":"2021111207265772000_21.10.543.78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00092.x"},{"key":"2021111207265772000_21.10.543.79","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209236"},{"key":"2021111207265772000_21.10.543.80","first-page":"81","article-title":"RNA-binding proteins and translational regulation in axons and growth cones","volume":"7","year":"2013","journal-title":"Front Neurosci"},{"key":"2021111207265772000_21.10.543.81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122205699"},{"key":"2021111207265772000_21.10.543.82","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)01036-9"},{"key":"2021111207265772000_21.10.543.83","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.009"},{"key":"2021111207265772000_21.10.543.84","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3289-0"},{"key":"2021111207265772000_21.10.543.85","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2207-13.2013"},{"key":"2021111207265772000_21.10.543.86","doi-asserted-by":"publisher","DOI":"10.1038\/nature04811"},{"key":"2021111207265772000_21.10.543.87","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3210"},{"key":"2021111207265772000_21.10.543.88","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1347-12.2012"},{"key":"2021111207265772000_21.10.543.89","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5280.1402"},{"key":"2021111207265772000_21.10.543.90","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.017"},{"key":"2021111207265772000_21.10.543.91","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291712002693"},{"key":"2021111207265772000_21.10.543.92","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.1.291"},{"key":"2021111207265772000_21.10.543.93","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960809)64:2<241::AID-AJMG1>3.0.CO;2-X"},{"key":"2021111207265772000_21.10.543.94","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-061109-134644"},{"key":"2021111207265772000_21.10.543.95","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013855108"},{"key":"2021111207265772000_21.10.543.96","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.10.049"},{"key":"2021111207265772000_21.10.543.97","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2638-05.2005"},{"key":"2021111207265772000_21.10.543.98","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00792"},{"key":"2021111207265772000_21.10.543.99","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e318287cd17"},{"key":"2021111207265772000_21.10.543.100","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.02.066"},{"key":"2021111207265772000_21.10.543.101","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710000520"},{"key":"2021111207265772000_21.10.543.102","doi-asserted-by":"publisher","DOI":"10.1038\/ng0895-483"},{"key":"2021111207265772000_21.10.543.103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ghir.2004.03.034"},{"key":"2021111207265772000_21.10.543.104","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81043-0"},{"key":"2021111207265772000_21.10.543.105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.01.038"},{"key":"2021111207265772000_21.10.543.106","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.122.2.293"},{"key":"2021111207265772000_21.10.543.107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.009"},{"key":"2021111207265772000_21.10.543.108","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.090852"},{"key":"2021111207265772000_21.10.543.109","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1102-04.2004"},{"key":"2021111207265772000_21.10.543.110","doi-asserted-by":"publisher","DOI":"10.1038\/nature06888"},{"key":"2021111207265772000_21.10.543.111","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.09.017"},{"key":"2021111207265772000_21.10.543.112","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009706"},{"key":"2021111207265772000_21.10.543.113","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10005"},{"key":"2021111207265772000_21.10.543.114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.11.004"},{"key":"2021111207265772000_21.10.543.115","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20308"},{"key":"2021111207265772000_21.10.543.116","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00731-6"},{"key":"2021111207265772000_21.10.543.117","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3670-08.2009"},{"key":"2021111207265772000_21.10.543.118","doi-asserted-by":"publisher","DOI":"10.1038\/297681a0"},{"key":"2021111207265772000_21.10.543.119","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1848.2004.00076.x"},{"key":"2021111207265772000_21.10.543.120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00824.x"},{"key":"2021111207265772000_21.10.543.121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb01499.x"},{"key":"2021111207265772000_21.10.543.122","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.031"},{"key":"2021111207265772000_21.10.543.123","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)03309-1"},{"key":"2021111207265772000_21.10.543.124","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3915-05.2006"},{"key":"2021111207265772000_21.10.543.125","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01316.2005"},{"key":"2021111207265772000_21.10.543.126","doi-asserted-by":"publisher","DOI":"10.1159\/000332884"},{"key":"2021111207265772000_21.10.543.127","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3888-10.2010"},{"key":"2021111207265772000_21.10.543.128","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.034"},{"key":"2021111207265772000_21.10.543.129","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.056127"},{"key":"2021111207265772000_21.10.543.130","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.09.085"},{"key":"2021111207265772000_21.10.543.131","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.01.003"},{"key":"2021111207265772000_21.10.543.132","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00285-7"},{"key":"2021111207265772000_21.10.543.133","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-10-91"},{"key":"2021111207265772000_21.10.543.134","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064200"},{"key":"2021111207265772000_21.10.543.135","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.8.1145"},{"key":"2021111207265772000_21.10.543.136","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2741"},{"key":"2021111207265772000_21.10.543.137","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.2.274"},{"key":"2021111207265772000_21.10.543.138","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90125-I"},{"key":"2021111207265772000_21.10.543.139","doi-asserted-by":"publisher","DOI":"10.1038\/nature12975"},{"key":"2021111207265772000_21.10.543.140","first-page":"33","article-title":"Speaking human","volume":"107","year":"2014","journal-title":"Tenn Med"},{"key":"2021111207265772000_21.10.543.141","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2963"},{"key":"2021111207265772000_21.10.543.142","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.05.050"},{"key":"2021111207265772000_21.10.543.143","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.03.013"},{"key":"2021111207265772000_21.10.543.144","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504984102"},{"key":"2021111207265772000_21.10.543.145","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2012.09.002"},{"key":"2021111207265772000_21.10.543.146","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70719-8"},{"key":"2021111207265772000_21.10.543.147","doi-asserted-by":"publisher","DOI":"10.1002\/bies.1083"},{"key":"2021111207265772000_21.10.543.148","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3033"},{"key":"2021111207265772000_21.10.543.149","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.12.041"},{"key":"2021111207265772000_21.10.543.150","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044816"},{"key":"2021111207265772000_21.10.543.151","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2013"},{"key":"2021111207265772000_21.10.543.152","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.09.001"},{"key":"2021111207265772000_21.10.543.153","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00354-4"},{"key":"2021111207265772000_21.10.543.154","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2007.72.018"},{"key":"2021111207265772000_21.10.543.155","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.25.561"},{"key":"2021111207265772000_21.10.543.156","first-page":"1016","article-title":"From FMRP function to potential therapies for fragile X syndrome","volume":"39","year":"2013","journal-title":"Neurochem Res"},{"key":"2021111207265772000_21.10.543.157","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200023)97:3<189::AID-AJMG1036>3.0.CO;2-J"},{"key":"2021111207265772000_21.10.543.158","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790170081009"},{"key":"2021111207265772000_21.10.543.159","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.008045"},{"key":"2021111207265772000_21.10.543.160","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2786-08.2008"},{"key":"2021111207265772000_21.10.543.161","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2005.00123.x"},{"key":"2021111207265772000_21.10.543.162","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl121"},{"key":"2021111207265772000_21.10.543.163","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.214098"},{"key":"2021111207265772000_21.10.543.164","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12518"},{"key":"2021111207265772000_21.10.543.165","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027100"},{"key":"2021111207265772000_21.10.543.166","doi-asserted-by":"publisher","DOI":"10.1242\/dev.015867"},{"key":"2021111207265772000_21.10.543.167","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2375-4"},{"key":"2021111207265772000_21.10.543.168","first-page":"803","article-title":"A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys","volume":"146","year":"2008","journal-title":"Am J Med Genet A"},{"key":"2021111207265772000_21.10.543.169","doi-asserted-by":"publisher","DOI":"10.1007\/BF01065446"},{"key":"2021111207265772000_21.10.543.170","doi-asserted-by":"publisher","DOI":"10.1007\/BF01350033"},{"key":"2021111207265772000_21.10.543.171","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3353"},{"key":"2021111207265772000_21.10.543.172","doi-asserted-by":"publisher","DOI":"10.1352\/1944-7558-115.5.433"},{"key":"2021111207265772000_21.10.543.173","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0061-13.2013"},{"key":"2021111207265772000_21.10.543.174","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00296-5"},{"key":"2021111207265772000_21.10.543.175","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.11.018"},{"key":"2021111207265772000_21.10.543.176","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200409000-00018"},{"key":"2021111207265772000_21.10.543.177","doi-asserted-by":"publisher","DOI":"10.1038\/363722a0"},{"key":"2021111207265772000_21.10.543.178","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90397-H"},{"key":"2021111207265772000_21.10.543.179","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2011.00763.x"},{"key":"2021111207265772000_21.10.543.180","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1416-y"},{"key":"2021111207265772000_21.10.543.181","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.22.8536-8547.2000"},{"key":"2021111207265772000_21.10.543.182","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1997)10:5<393::AID-HUMU10>3.0.CO;2-V"},{"key":"2021111207265772000_21.10.543.183","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173205"},{"key":"2021111207265772000_21.10.543.184","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2012.02.002"},{"key":"2021111207265772000_21.10.543.185","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407533101"},{"key":"2021111207265772000_21.10.543.186","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026549"},{"key":"2021111207265772000_21.10.543.187","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.05.055"},{"key":"2021111207265772000_21.10.543.188","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3567"},{"key":"2021111207265772000_21.10.543.189","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00087.x"},{"key":"2021111207265772000_21.10.543.190","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.06.004"},{"key":"2021111207265772000_21.10.543.191","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.09.023"},{"key":"2021111207265772000_21.10.543.192","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2005.00136.x"},{"key":"2021111207265772000_21.10.543.193","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00589-X"},{"key":"2021111207265772000_21.10.543.194","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.06.003"},{"key":"2021111207265772000_21.10.543.195","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003450"}],"container-title":["Learning &amp; Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/lm.035956.114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T15:57:04Z","timestamp":1717343824000},"score":1,"resource":{"primary":{"URL":"http:\/\/learnmem.cshlp.org\/lookup\/doi\/10.1101\/lm.035956.114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,16]]},"references-count":195,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,9,15]]},"published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1101\/lm.035956.114"],"URL":"https:\/\/doi.org\/10.1101\/lm.035956.114","relation":{},"ISSN":["1549-5485"],"issn-type":[{"value":"1549-5485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,16]]}}}