{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:33:39Z","timestamp":1790206419058,"version":"4.1.0"},"reference-count":78,"publisher":"Cold Spring Harbor Laboratory","issue":"8","funder":[{"DOI":"10.13039\/100012514","name":"Charles B.G. Murphy Fund","doi-asserted-by":"crossref","award":["DA015222"],"award-info":[{"award-number":["DA015222"]}],"id":[{"id":"10.13039\/100012514","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004823","name":"Connecticut Department of Mental Health and Addiction Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004823","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSF Graduate Research Fellowship Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Learn. Mem."],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Previously consolidated memories have the potential to enter a state of lability upon memory recall, during which time the memory can be altered before undergoing an additional consolidation-like process and being stored again as a long-term memory. Blocking reconsolidation of aberrant memories has been proposed as a potential treatment for psychiatric disorders including addiction. Here we investigated of the effect of systemically administering the protein synthesis inhibitor cycloheximide or the \u03b2-adrenergic antagonist propranolol on reconsolidation. Rats were trained to self-administer cocaine, during which each lever press resulted in the presentation of a cue paired with an intravenous infusion of cocaine. After undergoing lever press extinction to reduce operant responding, the cue memory was reactivated and rats were administered systemic injections of propranolol, cycloheximide, or vehicle. Post-reactivation cycloheximide, but not propranolol, resulted in a reactivation-dependent decrease in cue-induced reinstatement, indicative of reconsolidation blockade by protein synthesis inhibition. The present data indicate that systemically targeting protein synthesis as opposed to the \u03b2-adrenergic system may more effectively attenuate the reconsolidation of a drug-related memory and decrease drug-seeking behavior.<\/jats:p>","DOI":"10.1101\/lm.042838.116","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T02:43:35Z","timestamp":1468637015000},"page":"391-398","source":"Crossref","is-referenced-by-count":24,"title":["Inhibition of protein synthesis but not \u03b2-adrenergic receptors blocks reconsolidation of a cocaine-associated cue memory"],"prefix":"10.1101","volume":"23","author":[{"given":"Amber B.","family":"Dunbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"2021111207382691000_23.8.391.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.07.005"},{"key":"2021111207382691000_23.8.391.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039639"},{"key":"2021111207382691000_23.8.391.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.08.049"},{"key":"2021111207382691000_23.8.391.4","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3439"},{"key":"2021111207382691000_23.8.391.5","doi-asserted-by":"publisher","DOI":"10.1038\/nn1778"},{"key":"2021111207382691000_23.8.391.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000233098.20655.26"},{"key":"2021111207382691000_23.8.391.7","first-page":"412","article-title":"Noradrenergic blockade of memory reconsolidation: a failure to reduce conditioned fear responding","volume":"8","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"2021111207382691000_23.8.391.8","doi-asserted-by":"publisher","DOI":"10.1101\/lm.78804"},{"key":"2021111207382691000_23.8.391.9","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.59"},{"key":"2021111207382691000_23.8.391.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.018"},{"key":"2021111207382691000_23.8.391.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.02.014"},{"key":"2021111207382691000_23.8.391.12","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0009-15.2015"},{"key":"2021111207382691000_23.8.391.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.12.034"},{"key":"2021111207382691000_23.8.391.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.06.019"},{"key":"2021111207382691000_23.8.391.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.07.022"},{"key":"2021111207382691000_23.8.391.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.01.009"},{"key":"2021111207382691000_23.8.391.17","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1054608"},{"key":"2021111207382691000_23.8.391.18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3101-06.2006"},{"key":"2021111207382691000_23.8.391.19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1515\/rns.2011.023","article-title":"Modulation of fear memory by retrieval and extinction: a clue for memory deconsolidation","volume":"22","year":"2011","journal-title":"Rev Neurosci"},{"key":"2021111207382691000_23.8.391.20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/FBP.0000000000000074","article-title":"Stress-induced increases in depression-like and cocaine place-conditioned behaviors are reversed by disruption of memories during reconsolidation","volume":"25","year":"2014","journal-title":"Behav Pharmacol"},{"key":"2021111207382691000_23.8.391.21","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0934-14.2014"},{"key":"2021111207382691000_23.8.391.22","doi-asserted-by":"publisher","DOI":"10.1101\/lm.023408.111"},{"key":"2021111207382691000_23.8.391.23","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2271"},{"key":"2021111207382691000_23.8.391.24","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1029808"},{"key":"2021111207382691000_23.8.391.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.007"},{"key":"2021111207382691000_23.8.391.26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2466-06.2006"},{"key":"2021111207382691000_23.8.391.27","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.60"},{"key":"2021111207382691000_23.8.391.28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4818-05.2006"},{"key":"2021111207382691000_23.8.391.29","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1016\/S0924-977X(09)70099-9","article-title":"NMDA receptors and \u03b2-adrenergic receptors as molecular targets for the prevention of relapse to drug-seeking","volume":"19","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"2021111207382691000_23.8.391.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07249.x"},{"key":"2021111207382691000_23.8.391.31","doi-asserted-by":"publisher","DOI":"10.1101\/lm.825008"},{"key":"2021111207382691000_23.8.391.32","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2399-9"},{"key":"2021111207382691000_23.8.391.33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3273-12.2013"},{"key":"2021111207382691000_23.8.391.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.04.012"},{"key":"2021111207382691000_23.8.391.35","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1794710"},{"key":"2021111207382691000_23.8.391.36","doi-asserted-by":"publisher","DOI":"10.1038\/35021052"},{"key":"2021111207382691000_23.8.391.37","doi-asserted-by":"publisher","DOI":"10.1038\/35044580"},{"key":"2021111207382691000_23.8.391.38","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu082"},{"key":"2021111207382691000_23.8.391.39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3463-12.2013"},{"key":"2021111207382691000_23.8.391.40","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3797-6"},{"key":"2021111207382691000_23.8.391.41","doi-asserted-by":"crossref","unstructured":"Prus AJ , James JR , Rosecrans JA . 2009. Conditioned place preference. In Methods of behavior analysis in neuroscience. Frontiers in neuroscience (ed. Buccafusco JJ ), pp. 59\u201377. CRC Press\/Taylor & Francis, Boca Raton, FL. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK5229\/ (Accessed December 21, 2015).","DOI":"10.1201\/NOE1420052343.ch4"},{"key":"2021111207382691000_23.8.391.42","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1523\/JNEUROSCI.19-15-06623.1999","article-title":"Attenuation of emotional and nonemotional memories after their reactivation: role of \u03b2 adrenergic receptors","volume":"19","year":"1999","journal-title":"J Neurosci"},{"key":"2021111207382691000_23.8.391.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.05.023"},{"key":"2021111207382691000_23.8.391.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.04.056"},{"key":"2021111207382691000_23.8.391.45","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2011.00042"},{"key":"2021111207382691000_23.8.391.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.08.009"},{"key":"2021111207382691000_23.8.391.47","doi-asserted-by":"crossref","unstructured":"Rodriguez-Ortiz CJ , Bermudez-Rattoni F . 2007. Memory reconsolidation or updating consolidation? In Neural plasticity and memory: from genes to brain imaging (ed. Bermudez-Rattoni F ), CRC Press, Boca Raton, FL. http:\/\/europepmc.org\/abstract\/med\/21204424 (Accessed December 22, 2015).","DOI":"10.1201\/9781420008418"},{"key":"2021111207382691000_23.8.391.48","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3282effb81"},{"key":"2021111207382691000_23.8.391.49","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3039-3"},{"key":"2021111207382691000_23.8.391.50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3149-09.2010"},{"key":"2021111207382691000_23.8.391.51","first-page":"1103","article-title":"Bidirectional modulation of alcohol-associated memory reconsolidation through manipulation of adrenergic signaling","volume":"41","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"2021111207382691000_23.8.391.52","first-page":"227","article-title":"\u03b2-Adrenergic blockade during reactivation reduces the subjective feeling of remembering associated with emotional episodic memories","volume":"92","year":"2012","journal-title":"Biol Psychol"},{"key":"2021111207382691000_23.8.391.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.10.028"},{"key":"2021111207382691000_23.8.391.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075239"},{"key":"2021111207382691000_23.8.391.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.02.004"},{"key":"2021111207382691000_23.8.391.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.12.029"},{"key":"2021111207382691000_23.8.391.57","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12326"},{"key":"2021111207382691000_23.8.391.58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06323.x"},{"key":"2021111207382691000_23.8.391.59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1003152107"},{"key":"2021111207382691000_23.8.391.60","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-16522-6_13"},{"key":"2021111207382691000_23.8.391.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.027"},{"key":"2021111207382691000_23.8.391.62","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000088"},{"key":"2021111207382691000_23.8.391.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.08.002"},{"key":"2021111207382691000_23.8.391.64","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2750-9"},{"key":"2021111207382691000_23.8.391.65","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2015.07.006"},{"key":"2021111207382691000_23.8.391.66","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2090"},{"key":"2021111207382691000_23.8.391.67","doi-asserted-by":"publisher","DOI":"10.1038\/nn1628"},{"key":"2021111207382691000_23.8.391.68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511030103"},{"key":"2021111207382691000_23.8.391.69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107359"},{"key":"2021111207382691000_23.8.391.70","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1038\/srep03786","article-title":"Differential effects of propranolol on conditioned hyperactivity and locomotor sensitization induced by morphine in rats","volume":"4","year":"2014","journal-title":"Sci Rep"},{"key":"2021111207382691000_23.8.391.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.11.020"},{"key":"2021111207382691000_23.8.391.72","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1509909"},{"key":"2021111207382691000_23.8.391.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.09.005"},{"key":"2021111207382691000_23.8.391.74","first-page":"179","article-title":"Disruption of long-term alcohol-related memory reconsolidation: role of \u03b2-adrenoceptors and NMDA receptors","volume":"4","year":"2010","journal-title":"Front Behav Neurosci"},{"key":"2021111207382691000_23.8.391.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.08.008"},{"key":"2021111207382691000_23.8.391.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.04.004"},{"key":"2021111207382691000_23.8.391.77","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.03.025"},{"key":"2021111207382691000_23.8.391.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.06.050"}],"container-title":["Learning &amp; Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/lm.042838.116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:57:02Z","timestamp":1692428222000},"score":1,"resource":{"primary":{"URL":"http:\/\/learnmem.cshlp.org\/lookup\/doi\/10.1101\/lm.042838.116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":78,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,7,15]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1101\/lm.042838.116"],"URL":"https:\/\/doi.org\/10.1101\/lm.042838.116","relation":{},"ISSN":["1549-5485"],"issn-type":[{"value":"1549-5485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,15]]}}}