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Considerable variability within the CBS group on delayed recall performance led to the identification of memory-spared (<jats:italic>N<\/jats:italic> = 19) and memory-impaired (<jats:italic>N<\/jats:italic> = 25) subgroups. Whereas CBS-Spared showed no significant memory deficits, the CBS-Impaired subgroup were indistinguishable from typical AD across all episodic memory measures. Whole-brain voxel-based morphometry analyses implicated fronto-parietal and medial temporal regions in delayed recall performance in both the CBS-Impaired and AD groups. Furthermore, diffusion tensor imaging analyses revealed correlations between delayed recall performance and altered structural connectivity between fronto-parietal and frontotemporal regions in the CBS-Impaired group. Our findings underscore the importance of a distributed brain network including frontal, medial temporal, and parietal brain regions in supporting the capacity for successful episodic memory retrieval.<\/jats:p>","DOI":"10.1101\/lm.048454.118","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T18:45:18Z","timestamp":1560797118000},"page":"262-271","source":"Crossref","is-referenced-by-count":16,"title":["Fronto-parietal contributions to episodic retrieval\u2014evidence from neurodegenerative disorders"],"prefix":"10.1101","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-042X","authenticated-orcid":false,"given":"Siddharth","family":"Ramanan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-2582","authenticated-orcid":false,"given":"Cherie","family":"Strikwerda-Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annu","family":"Mothakunnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Hodges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6696-1440","authenticated-orcid":false,"given":"Olivier","family":"Piguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-8169","authenticated-orcid":false,"given":"Muireann","family":"Irish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"2021111208121594000_26.7.262.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.03.008"},{"key":"2021111208121594000_26.7.262.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.07.005"},{"key":"2021111208121594000_26.7.262.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0012-6"},{"key":"2021111208121594000_26.7.262.4","unstructured":"Andersson JLR , Jenkinson M , Smith S . 2007a. 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