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We found that males and females with a history of multiple shocks in one context had higher freezing levels during the SEFL test, relative to no shock controls, and that this SEFL effect persisted to a second test 30 days later. The dominant response was freezing in males and females, with no reliable sex differences at any stage of the SEFL procedure, but females also showed some unique escape-like behaviors on the days of trauma and mild stress exposure. In addition, females in the proestrus and estrus phases of the estrous cycle during the initial shock exposure showed increased SEFL relative to females in the metestrus and diestrus phases. These findings suggest that males and females show similar SEFL effects with freezing behavior, but that ovarian cycle phase at the time of trauma may alter the strength of SEFL in females.<\/jats:p>","DOI":"10.1101\/lm.054097.125","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T15:50:12Z","timestamp":1754581812000},"page":"a054097","source":"Crossref","is-referenced-by-count":4,"title":["Sex and estrous cycle effects on stress-enhanced fear learning in Long-Evans rats"],"prefix":"10.1101","volume":"32","author":[{"given":"Sofia A.","family":"Lopez-Kawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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