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In the current study, we examined the role of the CeA's connections to two midbrain dopamine regions, the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA), in processing CS information when predictions of reward or nonreward were confirmed or disconfirmed. Initially, two different retrograde tracers were injected into the SNc and the VTA of rats, to label CeA cells. Different groups of rats then received a visual CS either paired or unpaired with food. Finally, Fos induction was assessed after a test session in which rats were exposed to the visual CS alone or paired with food. Colabeling of Fos and the retrograde tracer(s) showed that CeA neurons projecting to the SNc, but not to the VTA, were engaged in processing CS information when the training and testing conditions differed. These results suggest that the CeA\u2013nigral pathway represents prediction error information during appetitive conditioning.<\/jats:p>","DOI":"10.1101\/lm.1889510","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T22:25:25Z","timestamp":1285971925000},"page":"531-538","source":"Crossref","is-referenced-by-count":51,"title":["The central amygdala projection to the substantia nigra reflects prediction error information in appetitive conditioning"],"prefix":"10.1101","volume":"17","author":[{"given":"Hongjoo J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"2021111109490175000_17.10.531.1","first-page":"1","article-title":"The catecholaminergic innervation of the rat amygdala","volume":"142","year":"1998","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"2021111109490175000_17.10.531.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05902.x"},{"key":"2021111109490175000_17.10.531.3","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1523\/JNEUROSCI.18-19-08038.1998","article-title":"Removal of cholinergic input to rat posterior parietal cortex disrupts incremental processing of conditioned stimuli","volume":"18","year":"1998","journal-title":"J Neurosci"},{"key":"2021111109490175000_17.10.531.4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90751-4"},{"key":"2021111109490175000_17.10.531.5","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.116.4.553"},{"key":"2021111109490175000_17.10.531.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09270.x"},{"key":"2021111109490175000_17.10.531.7","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1523\/JNEUROSCI.15-11-07315.1995","article-title":"Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing","volume":"15","year":"1995","journal-title":"J Neurosci"},{"key":"2021111109490175000_17.10.531.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4507-04.2005"},{"key":"2021111109490175000_17.10.531.9","doi-asserted-by":"crossref","unstructured":"Davis M . 2000. 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