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We also examined NE modulation of olfactory nerve\u2013evoked field potentials (ON-EFPs) in anesthetized normal and bulbar 5-HT depleted pups. Systemic injection of 2 mg\/kg isoproterenol (\u03b2-adrenoceptor agonist) induced odor preference learning, enhanced pCREB expression in the olfactory bulbs at 10 min after odor pairing, and increased ON-EFPs in normal rat pups but not in bulbar 5-HT-depleted rat pups. A dose of 6 mg\/kg isoproterenol, which was ineffective in modulating these measures in normal rat pups, induced odor preference learning, enhanced phosphorylated CREB (pCREB) expression, and increased ON-EFPs in bulbar 5-HT-depleted pups. These outcomes suggest that NE and 5-HT promote specific biochemical and electrophysiological changes that may critically underlie odor preference learning.<\/jats:p>","DOI":"10.1101\/lm.35900","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T00:00:34Z","timestamp":1027728034000},"page":"413-421","source":"Crossref","is-referenced-by-count":62,"title":["Isoproterenol Increases CREB Phosphorylation and Olfactory Nerve\u2013Evoked Potentials in Normal and 5-HT-Depleted Olfactory Bulbs in Rat Pups Only at Doses That Produce Odor Preference Learning"],"prefix":"10.1101","volume":"7","author":[{"given":"Qi","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn W.","family":"Harley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie C.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Darby-King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2021111106034886000_7.6.413.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00050-7"},{"key":"2021111106034886000_7.6.413.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81904-2"},{"key":"2021111106034886000_7.6.413.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00706-3"},{"key":"2021111106034886000_7.6.413.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81752-3"},{"key":"2021111106034886000_7.6.413.5","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1152\/jn.1994.71.6.2557","article-title":"Evidence for glutamate as the olfactory receptor cell neurotransmitter.","volume":"71","author":"Berkowicz","year":"1994","journal-title":"J. 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