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Performance on each problem was assessed by monitoring accuracy of choice behavior, and also by measuring latency to respond for fluid outcomes after odor sampling. During discrimination learning, rats in both lesioned groups had similar deficits, failing to show normal changes in response latency during learning, while at the same time exhibiting normal choice behavior relative to controls. Choice behavior was affected only during the reversal phase of training, in which OFC and ABL lesions produced distinctive deficits. Rats with ABL lesions were impaired on the first reversal (S1\u2212\/S2+), but were unimpaired at acquiring a reversal back to the original odor-outcome contigencies (S1+\/S2\u2212), whereas rats with OFC lesions were impaired on both types of reversals. These findings suggest that OFC and ABL serve partially overlapping roles in the use of incentive information that supports normal discrimination performance.<\/jats:p>","DOI":"10.1101\/lm.55203","type":"journal-article","created":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T18:04:20Z","timestamp":1048788260000},"page":"129-140","source":"Crossref","is-referenced-by-count":272,"title":["Lesions of Orbitofrontal Cortex and Basolateral Amygdala Complex Disrupt Acquisition of Odor-Guided Discriminations and Reversals"],"prefix":"10.1101","volume":"10","author":[{"given":"Geoffrey","family":"Schoenbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Setlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summer L.","family":"Nugent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Saddoris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2021111106142183000_10.2.129.1","doi-asserted-by":"crossref","first-page":"8954","DOI":"10.1523\/JNEUROSCI.20-23-08954.2000","article-title":"The effect of lesions of the insular cortex on instrumental conditioning: Evidence for a role in incentive memory.","volume":"20","author":"Balleine","year":"2000","journal-title":"J. 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