{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T16:48:15Z","timestamp":1698511695621},"reference-count":38,"publisher":"Cold Spring Harbor Laboratory","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Learn. Mem."],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>Synapses formed by the olfactory nerve (ON) provide the source of\nexcitatory synaptic input onto mitral cells (MC) in the olfactory bulb. These\nsynapses, which relay odor-specific inputs, are confined to the distally\ntufted single primary dendrites of MCs, the first stage of central olfactory\nprocessing. \u03b2-adrenergic modulation of electrical and chemical signaling\nat these synapses may be involved in early odor preference learning. To\ninvestigate this possibility, we combined electrophysiological recordings with\ncalcium imaging in olfactory bulb slices prepared from neonatal rats and mice.\nActivation of ON-MC synapses induced postsynaptic potentials, which were\nassociated with large postsynaptic calcium transients. Neither electrical nor\ncalcium responses were affected by \u03b2-adrenergic agonists or antagonist.\nImmunocytochemical analysis of MCs and their tufted dendrites revealed clear\nimmunoreactivity with antibodies against \u03b11A (Cav2.1, P\/Q-type) and\n\u03b11B (Cav2.2, N-type), but not against \u03b11C (Cav1.2, L-type) or\n\u03b11D (Cav1.3, L-type) calcium channel subunits. Moreover, nimodipine, a\nblocker of L-type calcium channels, had no effect on either electrical or\ncalcium signaling at ON-MC synapses. In contrast to previous evidence, we\nconcluded that in neonatal rats and mice (P5-P8), mitral cells do not express\nsignificant amounts of L-type calcium channels, the calcium channel type that\nis often targeted by \u03b2-adrenergic modulation. The absence of\n\u03b2-adrenergic modulation on either electrical or calcium signaling at\nON-MC synapses of neonatal rats and mice excludes the involvement of this\nmechanism in early odor preference learning.<\/jats:p>","DOI":"10.1101\/lm.75204","type":"journal-article","created":{"date-parts":[[2004,7,30]],"date-time":"2004-07-30T15:47:25Z","timestamp":1091202445000},"page":"406-411","source":"Crossref","is-referenced-by-count":13,"title":["Calcium Signaling in Mitral Cell Dendrites of Olfactory Bulbs of Neonatal Rats and Mice During Olfactory Nerve Stimulation and \u03b2-Adrenoceptor Activation"],"prefix":"10.1101","volume":"11","author":[{"given":"Qi","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mutoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Debarbieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kn\u00f6pfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2004,7,30]]},"reference":[{"key":"2021111106203687000_11.4.406.1","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1523\/JNEUROSCI.22-12-05239.2002","volume":"22","year":"2002","journal-title":"J. Neurosci."},{"key":"2021111106203687000_11.4.406.2","first-page":"230","volume":"647","year":"1995","journal-title":"Brain Res."},{"key":"2021111106203687000_11.4.406.3","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01058.2002"},{"key":"2021111106203687000_11.4.406.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(97)00042-2"},{"key":"2021111106203687000_11.4.406.5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1152\/jn.2000.84.1.39","volume":"84","year":"2000","journal-title":"J.\nNeurophysiol."},{"key":"2021111106203687000_11.4.406.6","doi-asserted-by":"publisher","DOI":"10.1038\/327620a0"},{"key":"2021111106203687000_11.4.406.7","doi-asserted-by":"publisher","DOI":"10.1038\/85109"},{"key":"2021111106203687000_11.4.406.8","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1152\/jn.2001.86.5.2173","volume":"86","year":"2001","journal-title":"J.\nNeurophysiol."},{"key":"2021111106203687000_11.4.406.9","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90295-V"},{"key":"2021111106203687000_11.4.406.10","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1523\/JNEUROSCI.16-03-01026.1996","volume":"16","year":"1996","journal-title":"J. Neurosci."},{"key":"2021111106203687000_11.4.406.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81013-2"},{"key":"2021111106203687000_11.4.406.12","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1523\/JNEUROSCI.16-19-06319.1996","volume":"16","year":"1996","journal-title":"J.\nNeurosci."},{"key":"2021111106203687000_11.4.406.13","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1152\/jn.1997.77.6.3013","volume":"77","year":"1997","journal-title":"J. Neurophysiol."},{"key":"2021111106203687000_11.4.406.14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960422)368:1<1::AID-CNE1>3.0.CO;2-7"},{"key":"2021111106203687000_11.4.406.15","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903040310"},{"key":"2021111106203687000_11.4.406.16","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902850305"},{"key":"2021111106203687000_11.4.406.17","unstructured":"McLean, J.H., McCann, J., Darby-King, A., and Harley, C.W.2003 . Not only \u03b2- but also \u03b1-adrenoceptors are involved in early odor preference learning in the rat. ACHEMS 26th annual meeting abstracts. P49 ."},{"key":"2021111106203687000_11.4.406.18","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903280409"},{"key":"2021111106203687000_11.4.406.19","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90148-9"},{"key":"2021111106203687000_11.4.406.20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90537-2"},{"key":"2021111106203687000_11.4.406.21","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90160-0"},{"key":"2021111106203687000_11.4.406.22","doi-asserted-by":"publisher","DOI":"10.1101\/lm.58203"},{"key":"2021111106203687000_11.4.406.23","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1523\/JNEUROSCI.09-11-03998.1989","volume":"9","year":"1989","journal-title":"J. Neurosci."},{"key":"2021111106203687000_11.4.406.24","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.114.5.957"},{"key":"2021111106203687000_11.4.406.25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(94)00265-G","volume":"30","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"2021111106203687000_11.4.406.26","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991018)413:2<289::AID-CNE9>3.0.CO;2-U"},{"key":"2021111106203687000_11.4.406.27","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1523\/JNEUROSCI.12-10-03992.1992","volume":"12","year":"1992","journal-title":"J. Neurosci."},{"key":"2021111106203687000_11.4.406.28","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90161-9"},{"key":"2021111106203687000_11.4.406.29","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1523\/JNEUROSCI.12-10-03985.1992","volume":"12","year":"1992","journal-title":"J. Neurosci."},{"key":"2021111106203687000_11.4.406.30","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90674-4"},{"key":"2021111106203687000_11.4.406.31","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1152\/jn.1996.75.3.1138","volume":"75","year":"1996","journal-title":"J. Neurophysiol."},{"key":"2021111106203687000_11.4.406.32","first-page":"69","volume":"470","year":"1988","journal-title":"Brain\nRes."},{"key":"2021111106203687000_11.4.406.33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-1047(05)80039-1","volume":"61","year":"1994","journal-title":"Behav. Neural."},{"key":"2021111106203687000_11.4.406.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00368-5"},{"key":"2021111106203687000_11.4.406.35","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903520102"},{"key":"2021111106203687000_11.4.406.36","doi-asserted-by":"publisher","DOI":"10.1101\/lm.35900"},{"key":"2021111106203687000_11.4.406.37","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1152\/jn.00917.2001","volume":"87","year":"2002","journal-title":"J. Neurophysiol."},{"key":"2021111106203687000_11.4.406.38","doi-asserted-by":"publisher","DOI":"10.1101\/lm.54803"}],"container-title":["Learning &amp; Memory"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/lm.75204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T14:26:40Z","timestamp":1636640800000},"score":1,"resource":{"primary":{"URL":"http:\/\/learnmem.cshlp.org\/lookup\/doi\/10.1101\/lm.75204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1101\/lm.75204"],"URL":"https:\/\/doi.org\/10.1101\/lm.75204","relation":{},"ISSN":["1072-0502","1549-5485"],"issn-type":[{"value":"1072-0502","type":"print"},{"value":"1549-5485","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}