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Second, the effect of deprivation is less persistent\nover time in adults than in juveniles. This correlates with the known decline\nin CREB function during maturation of the visual cortex. To compensate for\nthis decline in CREB function, we expressed persistently active VP16-CREB and\nfind that it causes adult plasticity to become persistent. These results\nsuggest that in development and adulthood, the regulation of a trans-synaptic\nsignaling pathway controls the adaptive potential of cortical circuits.<\/jats:p>","DOI":"10.1101\/lm.75304","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T01:26:04Z","timestamp":1100136364000},"page":"738-747","source":"Crossref","is-referenced-by-count":114,"title":["A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB"],"prefix":"10.1101","volume":"11","author":[{"given":"Tony A.","family":"Pham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Barco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Kandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin E.","family":"Lickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2004,11,10]]},"reference":[{"key":"2021111106215885000_11.6.738.1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00006324-198606000-00008","volume":"63","year":"1986","journal-title":"Am. 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