{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:32:50Z","timestamp":1787974370744,"version":"build-2784847793"},"reference-count":84,"publisher":"Cold Spring Harbor Laboratory","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Learn. Mem."],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>While studies of cerebellar involvement in learning and memory have\ndescribed plasticity within the cerebellum, its role in acquisition of\nplasticity elsewhere in the CNS is largely unexplored. This study set out to\ndetermine whether the cerebellum is needed for acquisition of the spinal cord\nplasticity that underlies operantly conditioned decrease in the H-reflex, the\nelectrical analog of the spinal stretch reflex. Rats in which the cerebellar\noutput nuclei dentate and interpositus (DIN) had been ablated were exposed for\n50 d to the H-reflex down-conditioning protocol. DIN ablation, which in itself\nhad no significant long-term effect on H-reflex size, entirely prevented\nacquisition of a smaller H-reflex. Since previous studies show that\ncorticospinal tract (CST) transection also prevents down-conditioning while\ntransection of the rubrospinal tract and other major descending tracts does\nnot, this result implies that DIN output that affects cortex is essential for\ngeneration of the CST activity that induces the spinal cord plasticity, which\nis, in turn, directly responsible for the smaller H-reflex. The result extends\nthe role of the cerebellum in learning and memory to include participation in\ninduction of plasticity elsewhere in the CNS, specifically in the spinal cord.\nThe cerebellum might simply support processes in sensorimotor cortex or\nelsewhere that change the spinal cord, or the cerebellum itself might undergo\nplasticity similar to that occurring with vestibulo-ocular reflex (VOR) or\neyeblink conditioning.<\/jats:p>","DOI":"10.1101\/lm.91305","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T22:58:20Z","timestamp":1117666700000},"page":"248-254","source":"Crossref","is-referenced-by-count":53,"title":["Ablation of cerebellar nuclei prevents H-reflex down-conditioning in rats"],"prefix":"10.1101","volume":"12","author":[{"given":"Xiang Yang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Wolpaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"2021111106243076000_12.3.248.1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1152\/physrev.1974.54.4.957","volume":"54","year":"1974","journal-title":"Physiol. 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