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These findings were considered against published scientific literature in order to evaluate the functional effects of potentially relevant genomic events. Analysis of the transcriptome against a background of 27 TCGA cancer types led to reclassification of the tumor as a primary HER2<jats:sup>+<\/jats:sup> mammary-like adenocarcinoma of the vulva. This revised diagnosis was subsequently confirmed by follow-up immunohistochemistry for a mammary-like adenocarcinoma. The patient was treated with chemotherapy and targeted therapies for HER2<jats:sup>+<\/jats:sup> breast cancer. The detailed pathology and genomic findings of this case are presented herein.<\/jats:p>","DOI":"10.1101\/mcs.a002170","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T04:29:56Z","timestamp":1504758596000},"page":"a002170","source":"Crossref","is-referenced-by-count":19,"title":["Detection and genomic characterization of a mammary-like adenocarcinoma"],"prefix":"10.1101","volume":"3","author":[{"given":"Jasleen K.","family":"Grewal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eirew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenrry","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basile","family":"Tessier-Cloutier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"Karnezis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aly","family":"Karsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Mungall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna V.","family":"Tinker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janessa","family":"Laskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Marra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"2021112506134672000_3.6.a002170.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000171601.25315.2b"},{"key":"2021112506134672000_3.6.a002170.2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.gore.2015.05.002","article-title":"Breast cancer metastasis to the vulva 20 years remote from initial diagnosis: a case report and literature review","volume":"13","year":"2015","journal-title":"Gynecol Oncol Rep"},{"key":"2021112506134672000_3.6.a002170.3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1053\/hupa.2002.124787","article-title":"Uroplakin-III to distinguish primary vulvar Paget disease from Paget disease secondary to urothelial carcinoma","volume":"33","year":"2002","journal-title":"Hum Pathol"},{"key":"2021112506134672000_3.6.a002170.4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.gynor.2013.09.001","article-title":"Primary invasive breast carcinoma arising in mammary-like glands of the vulva managed with excision and sentinel lymph node biopsy","volume":"7","year":"2014","journal-title":"Gynecol Oncol Case Rep"},{"key":"2021112506134672000_3.6.a002170.5","doi-asserted-by":"crossref","first-page":"e102398","DOI":"10.1371\/journal.pone.0102398","article-title":"JAGuaR: junction alignments to genome for RNA-seq reads","volume":"9","year":"2014","journal-title":"PLoS One"},{"key":"2021112506134672000_3.6.a002170.6","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu558"},{"key":"2021112506134672000_3.6.a002170.7","doi-asserted-by":"publisher","DOI":"10.4161\/fly.19695"},{"key":"2021112506134672000_3.6.a002170.8","doi-asserted-by":"publisher","DOI":"10.1309\/P756-XXCB-TV71-U4XV"},{"key":"2021112506134672000_3.6.a002170.9","doi-asserted-by":"publisher","DOI":"10.1111\/his.12034"},{"key":"2021112506134672000_3.6.a002170.10","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr629"},{"key":"2021112506134672000_3.6.a002170.11","doi-asserted-by":"publisher","DOI":"10.1101\/gr.137570.112"},{"key":"2021112506134672000_3.6.a002170.12","unstructured":"Hartung E . 1875. 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