{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:49:47Z","timestamp":1785527387924,"version":"3.56.0"},"reference-count":16,"publisher":"Cold Spring Harbor Laboratory","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Mol Case Stud"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>We report the case of a 27-yr-old male with visual field loss who had a 4.9-cm complex cystic mass in the right occipital lobe. Histologic examination showed pilocytic astrocytoma (PA) with anaplasia, and molecular characterization revealed <jats:italic>FGFR1<\/jats:italic> duplication with additional variants of unknown significance in several genes (<jats:italic>ARID1A, ARID1B, CHEK2, EPHA5,<\/jats:italic> and <jats:italic>MLL2<\/jats:italic>). This is one of only a very few reported cases of anaplastic PA with characterization of molecular alterations.<\/jats:p>","DOI":"10.1101\/mcs.a002378","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T13:45:21Z","timestamp":1522676721000},"page":"a002378","source":"Crossref","is-referenced-by-count":16,"title":["<i>FGFR1<\/i> tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia"],"prefix":"10.1101","volume":"4","author":[{"given":"Leomar Y.","family":"Ballester","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Penas-Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman E.","family":"Leeds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"Huse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory N.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"2021112406070422000_4.2.a002378.1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.jocn.2009.04.012","article-title":"Primary anaplastic pilocytic astrocytoma","volume":"16","year":"2009","journal-title":"J Clin Neurosci"},{"key":"2021112406070422000_4.2.a002378.2","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.18632\/oncotarget.12881","article-title":"Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumors","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"2021112406070422000_4.2.a002378.3","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1075"},{"key":"2021112406070422000_4.2.a002378.4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.clineuro.2012.01.034","article-title":"Cerebellar anaplastic pilocytic astrocytoma in a patient of neurofibromatosis type-1: case report and review of the literature","volume":"114","year":"2012","journal-title":"Clin Neurol Neurosurg"},{"key":"2021112406070422000_4.2.a002378.5","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21633"},{"key":"2021112406070422000_4.2.a002378.6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2682"},{"key":"2021112406070422000_4.2.a002378.7","unstructured":"Louis DN , Ohgaki H , Wiestler OD , Cavenee WK , Ellison DW , Figarella-Branger D , Perry A , Reifenberger G , von Deimling A , eds. 2016. 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