{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:21:10Z","timestamp":1782602470061,"version":"3.54.5"},"reference-count":34,"publisher":"Cold Spring Harbor Laboratory","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Mol Case Stud"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Neuroendocrine tumors (NETs) arising from tailgut cysts are a rare but increasingly reported entity with gene expression profiles that may be indicative of the gastrointestinal cell of origin. We present a case report describing the unique pathological and genomic characteristics of a tailgut cyst NET that metastasized to liver. The histologic and immunohistochemical findings were consistent with a well-differentiated NET. Genomic testing indicates a germline frameshift in <jats:italic>BRCA1<\/jats:italic> and a few somatic mutations of unknown significance. Transcriptomic analysis suggests an enteroendocrine L cell in the tailgut as a putative cell of origin. Genomic profiling of a rare NET and metastasis provides insight into its origin, development, and potential therapeutic options.<\/jats:p>","DOI":"10.1101\/mcs.a003004","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T20:19:43Z","timestamp":1533673183000},"page":"a003004","source":"Crossref","is-referenced-by-count":13,"title":["Surgical and molecular characterization of primary and metastatic disease in a neuroendocrine tumor arising in a tailgut cyst"],"prefix":"10.1101","volume":"4","author":[{"given":"Jennifer","family":"Erdrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt B.","family":"Schaberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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