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Tumor somatic expression profiles were analyzed to detect aberrant expression. Genomic and transcriptomic data sets were integrated to reveal dysregulation in pathways and identify potential therapeutic targets. Integrative genomic analysis with The Cancer Genome Atlas (TCGA) data set revealed the following outliers in gene expression profiles: <jats:italic>CDK6<\/jats:italic> (81st percentile), <jats:italic>MYC<\/jats:italic> (99th percentile), <jats:italic>AR<\/jats:italic> (100th percentile), <jats:italic>PDGFRA<\/jats:italic> and <jats:italic>PDGFRB<\/jats:italic> (99th and 100th percentiles, respectively), and <jats:italic>MAP2K2<\/jats:italic> (86th percentile). The patient received first-line sunitinib to target PDGFRA and PDGFRB and had stable disease for &gt;6 mo, followed by nivolumab upon progression. To the authors\u2019 knowledge, this is the first reported case of comprehensive somatic genomic analyses in a patient with metastatic TLFRCC. Somatic analyses provided molecular confirmation of the primary site of cancer and potential therapeutic strategies in a rare disease with little evidence of efficacy on systemic therapy.<\/jats:p>","DOI":"10.1101\/mcs.a003137","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T21:25:55Z","timestamp":1542403555000},"page":"a003137","source":"Crossref","is-referenced-by-count":16,"title":["Whole-genome and transcriptome profiling of a metastatic thyroid-like follicular renal cell carcinoma"],"prefix":"10.1101","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-2673","authenticated-orcid":false,"given":"Jenny J.","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasleen 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