{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:21:15Z","timestamp":1771654875727,"version":"3.50.1"},"reference-count":39,"publisher":"Cold Spring Harbor Laboratory","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Mol Case Stud"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>8p11 myeloproliferative syndrome (EMS) represents a unique World Health Organization (WHO)-classified hematologic malignancy defined by translocations of the FGFR1 receptor. The syndrome is a myeloproliferative neoplasm characterized by eosinophilia and lymphadenopathy, with risk of progression to either acute myeloid leukemia (AML) or T- or B-lymphoblastic lymphoma\/leukemia. Within the EMS subtype, translocations between <jats:italic>breakpoint cluster region<\/jats:italic> (<jats:italic>BCR<\/jats:italic>) and <jats:italic>fibroblast growth factor receptor 1<\/jats:italic> (<jats:italic>FGFR1<\/jats:italic>) have been shown to produce a dominant fusion protein that is notoriously resistant to tyrosine kinase inhibitors (TKIs). Here, we report two cases of <jats:italic>BCR\u2013FGFR1<\/jats:italic><jats:sup>+<\/jats:sup> EMS identified via RNA sequencing (RNA-seq) and confirmed by fluorescence in situ hybridization (FISH). Sanger sequencing revealed that both cases harbored the exact same breakpoint. In the first case, the patient presented with AML-like disease, and in the second, the patient progressed to B-cell acute lymphoblastic leukemia (B-ALL). Additionally, we observed that that primary leukemia cells from Case 1 demonstrated sensitivity to the tyrosine kinase inhibitors ponatinib and dovitinib that can target FGFR1 kinase activity, whereas primary cells from Case 2 were resistant to both drugs. Taken together, these results suggest that some but not all BCR\u2013FGFR1 fusion positive leukemias may respond to TKIs that target FGFR1 kinase activity.<\/jats:p>","DOI":"10.1101\/mcs.a004838","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T22:06:09Z","timestamp":1579903569000},"page":"a004838","source":"Crossref","is-referenced-by-count":7,"title":["Functional characterization of two rare BCR\u2013FGFR1<sup>+<\/sup> leukemias"],"prefix":"10.1101","volume":"6","author":[{"given":"Evan J.","family":"Barnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Leonard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-8137","authenticated-orcid":false,"given":"Bruno C.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Druker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-3078","authenticated-orcid":false,"given":"Cristina E.","family":"Tognon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"2021112506210627000_6.2.a004838.1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20442"},{"key":"2021112506210627000_6.2.a004838.2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080913"},{"key":"2021112506210627000_6.2.a004838.3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"2021112506210627000_6.2.a004838.4","doi-asserted-by":"crossref","unstructured":"Arsham MS , Shaffer LG . 2017. 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