{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:30:11Z","timestamp":1752669011726,"version":"3.37.3"},"reference-count":36,"publisher":"Cold Spring Harbor Laboratory","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Mol Case Stud"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Although combination therapy with RAF and EGFR inhibitors has improved the survival outcomes of patients with <jats:italic>BRAF<\/jats:italic>-mutated colorectal cancer (CRC), acquired resistance invariably develops. The mechanisms of acquired resistance to RAF inhibitors have been largely attributed to activating mutations in <jats:italic>RAS<\/jats:italic>genes, <jats:italic>MAP2K<\/jats:italic> mutations, and amplifications in <jats:italic>BRAF<\/jats:italic>, <jats:italic>RAS<\/jats:italic> genes, and <jats:italic>EGFR<\/jats:italic>. In this report, we describe a patient with <jats:italic>BRAF<\/jats:italic>-mutated CRC who acquired an amino-terminal <jats:italic>BRAF<\/jats:italic> deletion involving the Ras-binding domain (RBD) after treatment with RAF\/EGFR inhibitor therapy. Amino-terminal <jats:italic>BRAF<\/jats:italic> deletions involving the RBD are a rare mechanism of acquired resistance to RAF inhibitors, particularly in CRC for which there is only one prior report in the literature.<\/jats:p>","DOI":"10.1101\/mcs.a005140","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:02:39Z","timestamp":1594857759000},"page":"a005140","source":"Crossref","is-referenced-by-count":2,"title":["An amino-terminal <i>BRAF<\/i> deletion accounting for acquired resistance to RAF\/EGFR inhibition in colorectal cancer"],"prefix":"10.1101","volume":"6","author":[{"given":"Jack K.","family":"Tung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Neishaboori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigurdis","family":"Haraldsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4531-9723","authenticated-orcid":false,"given":"Carlos J.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2020,7,15]]},"reference":[{"key":"2021112506215535000_6.4.a005140.1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-1518"},{"key":"2021112506215535000_6.4.a005140.2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11252"},{"key":"2021112506215535000_6.4.a005140.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"2021112506215535000_6.4.a005140.4","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2078-6891.2015.076"},{"key":"2021112506215535000_6.4.a005140.5","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1226"},{"key":"2021112506215535000_6.4.a005140.6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.3557"},{"key":"2021112506215535000_6.4.a005140.7","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.15_suppl.3514"},{"key":"2021112506215535000_6.4.a005140.8","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0050"},{"key":"2021112506215535000_6.4.a005140.9","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1746"},{"key":"2021112506215535000_6.4.a005140.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502309"},{"key":"2021112506215535000_6.4.a005140.11","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12674"},{"key":"2021112506215535000_6.4.a005140.12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.4394"},{"key":"2021112506215535000_6.4.a005140.13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.2497"},{"key":"2021112506215535000_6.4.a005140.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908075"},{"key":"2021112506215535000_6.4.a005140.15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0758"},{"key":"2021112506215535000_6.4.a005140.16","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0827"},{"key":"2021112506215535000_6.4.a005140.17","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0396"},{"key":"2021112506215535000_6.4.a005140.18","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2166"},{"key":"2021112506215535000_6.4.a005140.19","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2954"},{"key":"2021112506215535000_6.4.a005140.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature10662"},{"key":"2021112506215535000_6.4.a005140.21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3122"},{"key":"2021112506215535000_6.4.a005140.22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29825"},{"key":"2021112506215535000_6.4.a005140.23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.3452"},{"key":"2021112506215535000_6.4.a005140.24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0404"},{"key":"2021112506215535000_6.4.a005140.25","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0642"},{"key":"2021112506215535000_6.4.a005140.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112302"},{"key":"2021112506215535000_6.4.a005140.27","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S118897"},{"key":"2021112506215535000_6.4.a005140.28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.5892"},{"key":"2021112506215535000_6.4.a005140.29","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25555"},{"key":"2021112506215535000_6.4.a005140.30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0904160"},{"key":"2021112506215535000_6.4.a005140.31","doi-asserted-by":"publisher","DOI":"10.2147\/gictt.s125940"},{"key":"2021112506215535000_6.4.a005140.32","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.250"},{"key":"2021112506215535000_6.4.a005140.33","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2779"},{"key":"2021112506215535000_6.4.a005140.34","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0768"},{"key":"2021112506215535000_6.4.a005140.35","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2004"},{"key":"2021112506215535000_6.4.a005140.36","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0274-5"}],"container-title":["Molecular Case Studies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/mcs.a005140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T14:22:04Z","timestamp":1637850124000},"score":1,"resource":{"primary":{"URL":"http:\/\/molecularcasestudies.cshlp.org\/lookup\/doi\/10.1101\/mcs.a005140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8,25]]},"published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1101\/mcs.a005140"],"URL":"https:\/\/doi.org\/10.1101\/mcs.a005140","relation":{},"ISSN":["2373-2865","2373-2873"],"issn-type":[{"type":"print","value":"2373-2865"},{"type":"electronic","value":"2373-2873"}],"subject":[],"published":{"date-parts":[[2020,7,15]]}}}