{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:09:48Z","timestamp":1767276588943},"reference-count":38,"publisher":"Cold Spring Harbor Laboratory","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cold Spring Harb Mol Case Stud"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Myeloid\/lymphoid neoplasms with<jats:italic>FLT3<\/jats:italic>gene fusions have recently been included among myeloid\/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK) in the World Health Organization classification and International Consensus Classification. As this entity remains remarkably rare, its scope and phenotypic features are evolving. In this report, we describe a 33-yr-old male with MLN-TK. Conventional chromosome analysis revealed a t(13;14)(q12;q32). Further analysis with mate-pair sequencing (MPseq) confirmed a<jats:italic>TRIP11::FLT3<\/jats:italic>gene fusion. A diagnosis of MLN-TK was rendered. To the best of our knowledge, we report the third case of MLN-TK with a<jats:italic>TRIP11::FLT3<\/jats:italic>gene fusion. In contrast to previously described cases, our case exhibited distinctly mild clinical features and disease behavior, emphasizing the diverse spectrum of MLN-TK at primary presentation and variability in disease course. MLN-TK with<jats:italic>FLT3<\/jats:italic>gene fusions are a genetically defined entity which may be targetable with tyrosine kinase inhibitors with anti-FLT3 activity. Accordingly, from diagnostic and therapeutic viewpoints, genetic testing for<jats:italic>FLT3<\/jats:italic>rearrangements using fluorescence in situ hybridization (FISH) or sequencing-based assays should be pursued for patients with chronic eosinophilia.<\/jats:p>","DOI":"10.1101\/mcs.a006243","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T16:10:18Z","timestamp":1673367018000},"page":"a006243","source":"Crossref","is-referenced-by-count":6,"title":["A<i>TRIP11:: FLT3<\/i>gene fusion in a patient with myeloid\/lymphoid neoplasm with eosinophilia and tyrosine kinase gene fusions: a case report and review of the literature"],"prefix":"10.1101","volume":"9","author":[{"given":"Elise R.","family":"Venable","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Pitel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne M.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jess F.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda B.","family":"Baughn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole L.","family":"Hoppman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia T.","family":"Greipp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhett P.","family":"Ketterling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal S.","family":"Patnaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Kelemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"2023032408550861000_9.1.a006243.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.11.4271"},{"key":"2023032408550861000_9.1.a006243.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"2023032408550861000_9.1.a006243.3","doi-asserted-by":"crossref","unstructured":"Arsham MS , Barch MJ , Lawce HJ . 2017. 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