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This remarkable genetic similarity, together with our ability to finely engineer the murine genome, has made the mouse the ideal animal in which to model and analyze human biology and disease. Here we describe this remarkable shared journey between human and mouse, and envisage the next generation of mouse models, which will no doubt prove increasingly sophisticated and even more faithful to human disease. We also address the strategic use of mice in the fight against cancer, and the role they will play in the development of therapies to eradicate this disease.<\/jats:p>","DOI":"10.1101\/pdb.top069757","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T16:17:56Z","timestamp":1388074676000},"page":"pdb.top069757","source":"Crossref","is-referenced-by-count":10,"title":["Of Model Pets and Cancer Models: An Introduction to Mouse Models of Cancer"],"prefix":"10.1101","volume":"2014","author":[{"given":"Andrea","family":"Lunardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Nardella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Clohessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier 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