{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:44:03Z","timestamp":1768553043456,"version":"3.49.0"},"posted":{"date-parts":[[2021,8,9]]},"group-title":"Infectious Diseases (except HIV\/AIDS)","reference-count":27,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,8,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Children and adolescents with Covid-19 have been shown lower mortality less intense symptoms when compared to adults, but studies in Brazil have been based on the compulsory notifying system only.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To analyse clinical, laboratory, radiological characteristics and outcomes of hospitalized patients under 20 years with Covid-19.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cases series of hospitalized patients with confirmed Covid-19 under 20 years, obtained from a cohort study in 37 hospitals from five states of Brazil.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From 36 patients, 20 (55.5%) were adolescentes, 20 (55.5%) were male, 18 (50.0%) had comorbidities, 2 were pregnant and in 7 (19.4%), initial symptoms occurred during hospitalization for other causes, of whom 3 were possibly infected in the hospital. Fever (61.1%), dyspnea (33.3%) and neurological symptoms (33.0%) were the most common complaints. C-reactive protein was higher than 50mg\/L in 16.7% and D-dimer was above the reference limit in 22.2%. Chest X-rays were performed in 20 (55.5%) patients, 9 had abnormalities, and chest tomography in 5. Hospital length of stay ranged from 1-40 days (median 5 [interquartile range 3-10]), 16 (44.4%) needed intensive therapy, 6 (16.7%) required mechanical ventilation and one patient (2.8%) died.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In case series patients under 20 years from hospitals from 5 states of Brazil, comorbidities were frequent, and most common symptoms were fever, dyspnea and neurological symptoms. Forty-four percent required intensive therapy, showing that the disease was not as mild as it was expected, and one patient died.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2021.08.08.21261510","type":"posted-content","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T15:24:41Z","timestamp":1628522681000},"source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 in Brazilian children and adolescents: findings from 21 hospitals"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-8503","authenticated-orcid":false,"given":"Priscila Menezes Ferri","family":"Liu","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-0364","authenticated-orcid":false,"given":"Maria do Carmo Barros","family":"de Melo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-4377","authenticated-orcid":false,"given":"Lilian Martins Oliveira","family":"Diniz","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-3300","authenticated-orcid":false,"given":"Cristiane dos Santos","family":"Dias","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-1186","authenticated-orcid":false,"given":"Andr\u00e9 Soares","family":"de Moura Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-1093","authenticated-orcid":false,"given":"B\u00e1rbara Lopes","family":"Farace","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-4494","authenticated-orcid":false,"given":"Carla Thais Candida Alves","family":"da Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-5406","authenticated-orcid":false,"given":"Fernando","family":"Anschau","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9173-8892","authenticated-orcid":false,"given":"Fernando Gra\u00e7a","family":"Aranha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-7067","authenticated-orcid":false,"given":"Guilherme Fagundes","family":"Nascimento","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9345-018X","authenticated-orcid":false,"given":"Helena","family":"Duani","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7577-6060","authenticated-orcid":false,"given":"Jamille Hem\u00e9trio Salles Martins","family":"Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6362-1889","authenticated-orcid":false,"given":"Karen Brasil","family":"Ruschel","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0241-9046","authenticated-orcid":false,"given":"Matheus Carvalho Alves","family":"Nogueira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-9459","authenticated-orcid":false,"given":"Neimy Ramos","family":"de Oliveira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1733-6398","authenticated-orcid":false,"given":"Roberta","family":"Pozza","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9655-6294","authenticated-orcid":false,"given":"Saionara Cristina","family":"Francisco","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-0124","authenticated-orcid":false,"given":"Thalita Martins","family":"Lage","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0730-8716","authenticated-orcid":false,"given":"Yuri Carlotto","family":"Ramires","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-9322","authenticated-orcid":false,"given":"Daniella Nunes","family":"Pereira","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6374-9295","authenticated-orcid":false,"given":"Zilma Silveira Nogueira","family":"Reis","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4343-025X","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Chatkin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-3771","authenticated-orcid":false,"given":"Milena Soriano","family":"Marcolino","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"issue":"3","key":"2021081106300793000_2021.08.08.21261510v1.1","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1016\/S2542-5196(20)30301-6","article-title":"The relationship between cultural tightness-looseness and COVID-19 cases and deaths: a global analysis","volume":"5","year":"2021","journal-title":"Lancet Planet Health"},{"issue":"1","key":"2021081106300793000_2021.08.08.21261510v1.2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa2102968","article-title":"BATS Consortium. 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