{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:17:51Z","timestamp":1768551471559,"version":"3.49.0"},"posted":{"date-parts":[[2021,11,21]]},"group-title":"Cardiovascular Medicine","reference-count":52,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2021,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>The harmful effects of coronavirus disease 2019 (COVID-19) can reach the autonomic nervous system (ANS) and endothelial function. Therefore, the detrimental multiorgan effects of COVID-19 could be induced by deregulations in ANS that may persist after the acute SARS-CoV-2 infection. Additionally, investigating the differences in ANS response in overweight\/obese, and physically inactive participants who had COVID-19 compared to those who did not have the disease is necessary. The aim of the study was to analyze the autonomic function of young adults after mild-to-moderate infection with COVID-19 and to assess whether body mass index (BMI) and levels of physical activity modulates autonomic function in participants with and without COVID-19. Patients previously infected with COVID-19 and healthy controls were recruited for this cross-sectional observational study. A general anamnesis was taken and BMI and physical activity levels were assessed. The ANS was evaluated through heart rate variability. A total of 57 subjects were evaluated. Sympathetic nervous system activity in post-COVID-19 group was increased (stress index; p=0.0273). They also presented lower values of parasympathetic activity (p&lt;0.05). Overweight\/obese subjects in the post-COVID-19 group presented significantly lower parasympathetic activity and reduced global variability compared to non-obese in control group (p&lt;0.05). Physically inactive subjects in post-COVID-19 group presented significantly higher sympathetic activity than active subjects in control group. Parasympathetic activity was significantly increased in physically active subjects in control group compared to the physically inactive post-COVID-19 group (p&lt;0.05). COVID-19 promotes changes in the ANS of young adults, and these changes are modulated by Overweight\/obesity and physical activity levels.<\/jats:p>\n                <jats:sec>\n                  <jats:title>Key Points<\/jats:title>\n                  <jats:list list-type=\"simple\">\n                    <jats:list-item>\n                      <jats:label>\u2010<\/jats:label>\n                      <jats:p>Our main finding is that even in mild and moderate infections, young adults who had COVID-19 had greater sympathetic activity, less parasympathetic activity, and global variability when compared to uninfected individuals.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:label>\u2010<\/jats:label>\n                      <jats:p>In participants who were overweight and obese and\/or physically inactive, cardiac autonomic modulation showed worse indices.<\/jats:p>\n                    <\/jats:list-item>\n                    <jats:list-item>\n                      <jats:label>\u2010<\/jats:label>\n                      <jats:p>Our study provides new insights regarding the role of body mass index and physical activity status on post-COVID-19 infection autonomic deregulation that may contribute to the understand of pathophysiology and treatment of of post-acute sequelae SARS-CoV-2 infection.<\/jats:p>\n                    <\/jats:list-item>\n                  <\/jats:list>\n                <\/jats:sec>","DOI":"10.1101\/2021.11.17.21266473","type":"posted-content","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T19:50:15Z","timestamp":1637524215000},"source":"Crossref","is-referenced-by-count":1,"title":["ROLE OF BODY MASS AND PHYSICAL ACTIVITY IN AUTONOMIC FUNCTION MODULATION ON POST-COVID-19 CONDITION: AN OBSERVATIONAL SUBANALYSIS OF FIT-COVID STUDY"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-5746","authenticated-orcid":false,"given":"Ana Paula Coelho","family":"Figueira Freire","sequence":"first","affiliation":[]},{"given":"Fabio Santos","family":"de Lira","sequence":"additional","affiliation":[]},{"given":"Ana Elisa","family":"von Ah Morano","sequence":"additional","affiliation":[]},{"given":"Telmo","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Manuel-Jo\u00e3o Coelho","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Armando","family":"Caseiro","sequence":"additional","affiliation":[]},{"given":"Diego Giulliano","family":"Destro Christofaro","sequence":"additional","affiliation":[]},{"given":"Osmar Marchioto","family":"J\u00fanior","sequence":"additional","affiliation":[]},{"given":"Gilson Pires","family":"Dorneles","sequence":"additional","affiliation":[]},{"given":"Ricardo Aurino","family":"Pinho","sequence":"additional","affiliation":[]},{"given":"Bruna Spolador","family":"de Alencar Silva","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"issue":"17","key":"2021112321550472000_2021.11.17.21266473v1.1","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1111\/febs.15375","article-title":"A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2","volume":"287","year":"2020","journal-title":"The FEBS journal"},{"issue":"3","key":"2021112321550472000_2021.11.17.21266473v1.2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4014\/jmb.2003.03011","article-title":"Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19)","volume":"30","year":"2020","journal-title":"Journal of microbiology and biotechnology"},{"key":"2021112321550472000_2021.11.17.21266473v1.3","doi-asserted-by":"crossref","unstructured":"Go\u00ebrtz Ymj , Van Herck M , Delbressine JM , Vaes AW , Meys R , Machado FVC , et al. 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