{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:19:22Z","timestamp":1768555162705,"version":"3.49.0"},"posted":{"date-parts":[[2022,5,31]]},"group-title":"Oncology","reference-count":67,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Ultraviolet radiation (UV) is causally linked to cutaneous melanoma, yet the underlying epigenetic mechanisms, known as molecular sensors of exposure, have never been characterized in clinical biospecimen. Here, we integrate clinical and epigenome (DNA methylome), genome and transcriptome profiling of 112 cutaneous melanoma from two multi-ethnic cohorts. We identify UV-related alterations in regulatory regions and immunological pathways, with multi-OMICs cancer driver potential affecting patient survival.\n                  <jats:italic>TAPBP<\/jats:italic>\n                  , the top gene, is critically involved in immune function and encompasses several UV-altered methylation sites that were validated by targeted sequencing, providing cost-effective opportunities for clinical application. The DNA methylome also reveals non UV-related aberrations underlying pathological differences between the cutaneous and 17 acral melanomas. Unsupervised epigenomic mapping demonstrated that non UV-mutant cutaneous melanoma more closely resembles acral rather than UV-exposed cutaneous melanoma, with the latter showing better patient prognosis than the other two forms. These gene-environment interactions reveal translationally impactful mechanisms in melanomagenesis.\n                <\/jats:p>","DOI":"10.1101\/2022.05.30.22275777","type":"posted-content","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:31Z","timestamp":1654041631000},"source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure"],"prefix":"10.64898","author":[{"given":"Anna Luiza Silva Almeida","family":"Vicente","sequence":"first","affiliation":[]},{"given":"Alexei","family":"Novoloaca","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Cahais","sequence":"additional","affiliation":[]},{"given":"Zainab","family":"Awada","sequence":"additional","affiliation":[]},{"given":"Cyrille","family":"Cuenin","sequence":"additional","affiliation":[]},{"given":"Nat\u00e1lia","family":"Spitz","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9 Lopes","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Adriane Feij\u00f3","family":"Evangelista","sequence":"additional","affiliation":[]},{"given":"Camila Souza","family":"Crovador","sequence":"additional","affiliation":[]},{"given":"Rui Manuel","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Zdenko","family":"Herceg","sequence":"additional","affiliation":[]},{"given":"Vinicius","family":"de Lima Vazquez","sequence":"additional","affiliation":[]},{"given":"Akram","family":"Ghantous","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"key":"2022060301350573000_2022.05.30.22275777v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21935"},{"key":"2022060301350573000_2022.05.30.22275777v1.2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.191999.112"},{"key":"2022060301350573000_2022.05.30.22275777v1.3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2022060301350573000_2022.05.30.22275777v1.4","first-page":"591","article-title":"Vital signs: melanoma incidence and mortality trends and projections -United States, 1982-2030","volume":"64","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2022060301350573000_2022.05.30.22275777v1.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4757"},{"key":"2022060301350573000_2022.05.30.22275777v1.6","first-page":"705","article-title":"The histogenesis and biologic behavior of primary human malignant melanomas of the skin","volume":"29","year":"1969","journal-title":"Cancer Res"},{"key":"2022060301350573000_2022.05.30.22275777v1.7","doi-asserted-by":"crossref","unstructured":"Bernardes, S.S. et al. More than just acral melanoma: the controversies of defining the disease. 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