{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:06:21Z","timestamp":1768554381479,"version":"3.49.0"},"posted":{"date-parts":[[2022,11,11]]},"group-title":"Oncology","reference-count":57,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2022,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The Canadian Cancer Registry does not collect demographic data beyond age and sex, making it hard to monitor health inequalities in cancer incidence in Canada, a country with public healthcare and many immigrants. Using data linkage, we compared site-specific cancer incidence rates by race.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used data from the 2006 and 2011 Canadian Census Health and Environment Cohorts (CanCHECs), which are population-based probabilistically linked datasets of 5.9 million respondents of the 2006 Canadian long-form census and 6.5 million respondents of the 2011 National Household Survey. Respondents\u2019 race was self-reported using Indigenous identity and visible minority group identity questions. Respondent data were linked with the Canadian Cancer Registry up to 2015. We calculated age-standardized incidence rate ratios (ASIRR), comparing group-specific rates to the overall population rate with bootstrapped 95% confidence intervals (95%CI). We used negative binomial regressions to adjust rates for socioeconomic variables and assess interactions with immigration status.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The age-standardized cancer incidence rate was lower in almost all non-White racial groups than in White individuals, except for Indigenous peoples who had a similar overall age-standardized cancer incidence rate (ASIRR 0.99, 95%CI 0.97-1.01). Immigrants had substantially lower age-standardized overall cancer incidence rates than non-immigrants (ASIRR 0.83, 95%CI 0.82-0.84). Non-White racial groups generally had significantly lower or equivalent site-specific cancer incidence rates than the overall population, except for stomach, liver, and thyroid cancers and for multiple myeloma. Differences in incidence rates by race persisted even after adjusting for household income, education, and rural residence, with immigration status being an important modifier of cancer risk.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Differences in cancer incidence between racial groups are likely influenced by differences in lifestyles and early life exposures, as well as selection factors for immigration. This suggests a strong role of environment in determining cancer risk and further potential for cancer prevention.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/2022.11.09.22281329","type":"posted-content","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T16:25:14Z","timestamp":1668183914000},"source":"Crossref","is-referenced-by-count":0,"title":["Site-specific cancer incidence by race and immigration status in Canada 2006-2015: a population-based data linkage study"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-3564","authenticated-orcid":false,"given":"Tal\u00eda","family":"Malag\u00f3n","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-0179","authenticated-orcid":false,"given":"Samantha","family":"Morais","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-1413","authenticated-orcid":false,"given":"Parker","family":"Tope","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-0370","authenticated-orcid":false,"given":"Mariam","family":"El-Zein","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-8084","authenticated-orcid":false,"given":"Eduardo L","family":"Franco","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"key":"2022111400201222000_2022.11.09.22281329v1.1","unstructured":"American Association for Cancer Research. 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