{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:24:55Z","timestamp":1768566295464,"version":"3.49.0"},"posted":{"date-parts":[[2023,10,19]]},"group-title":"Neurology","reference-count":53,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2025,3,4]]},"abstract":"<jats:p>\n                  A polygenic score (PGS) for Alzheimer\u2019s disease (AD) was recently derived from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with AD risk, age at onset, and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E\n                  <jats:italic>(APOE)<\/jats:italic>\n                  . This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score (PRS) improved the association with AD risk in most of the multi-ancestry populations tested when the\n                  <jats:italic>APOE<\/jats:italic>\n                  region was included. Lastly, we found that the PGS\/PRS, captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, but studies of more diverse populations are still needed for a better characterization of the AD genetics.\n                <\/jats:p>","DOI":"10.1101\/2023.10.17.23297061","type":"posted-content","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T16:25:21Z","timestamp":1697732721000},"source":"Crossref","is-referenced-by-count":0,"title":["Transferability of European-derived Alzheimer\u2019s Disease Polygenic Risk Scores across Multi-Ancestry 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