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Chai-1 can optionally be prompted with experimental restraints (e.g. derived from wet-lab data) which boosts performance by double-digit percentage points. Chai-1 can also be run in single-sequence mode with-out MSAs while preserving most of its performance. We release Chai-1 model weights and inference code as a Python package for non-commercial use and via a web interface where it can be used for free including for commercial drug discovery purposes.<\/jats:p>","DOI":"10.1101\/2024.10.10.615955","type":"posted-content","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T22:55:14Z","timestamp":1728687314000},"source":"Crossref","is-referenced-by-count":469,"title":["Chai-1: Decoding the molecular interactions of life"],"prefix":"10.64898","author":[{"name":"Chai Discovery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Boitreaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Dent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McPartlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Rogozhnikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2024101811100688000_2024.10.10.615955v2.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2004.11.020"},{"key":"2024101811100688000_2024.10.10.615955v2.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15459-7"},{"key":"2024101811100688000_2024.10.10.615955v2.3","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1016071"},{"key":"2024101811100688000_2024.10.10.615955v2.4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112783"},{"key":"2024101811100688000_2024.10.10.615955v2.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102548"},{"key":"2024101811100688000_2024.10.10.615955v2.6","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-021-03819-2"},{"key":"2024101811100688000_2024.10.10.615955v2.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8754"},{"key":"2024101811100688000_2024.10.10.615955v2.8","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"2024101811100688000_2024.10.10.615955v2.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-02086-5"},{"key":"2024101811100688000_2024.10.10.615955v2.10","doi-asserted-by":"publisher","DOI":"10.1126\/sci-ence.adl2528"},{"key":"2024101811100688000_2024.10.10.615955v2.11","unstructured":"Josh Abramson , Jonas Adler , Jack Dunger , Richard Evans , Tim Green , Alexander Pritzel , Olaf Ronneberger , Lindsay Willmore , Andrew J Ballard , Joshua Bambrick , et al. 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